IGLL1 and FAT1

Data Source:
BioGRID (two hybrid)

		IGLL1	FAT1
Description		immunoglobulin lambda like polypeptide 1	FAT atypical cadherin 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum External Side Of Plasma Membrane Membrane Immunoglobulin Complex, Circulating	Nucleus Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Focal Adhesion Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Antigen Binding Protein Binding Immunoglobulin Receptor Binding	Calcium Ion Binding Protein Binding
	Biological Process	Phagocytosis, Recognition Phagocytosis, Engulfment Immune Response Complement Activation, Classical Pathway Defense Response To Bacterium Innate Immune Response B Cell Receptor Signaling Pathway Positive Regulation Of B Cell Activation Leukocyte Migration	Actin Filament Organization Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Establishment Or Maintenance Of Cell Polarity Cell-cell Signaling Anatomical Structure Morphogenesis Cell Migration Cell-cell Adhesion
Pathways		Cell surface interactions at the vascular wall
Drugs		Copper
Diseases		Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8
GWAS		Blood protein levels ( 30072576 29875488) Height ( 18391951) HOMA-B (corrected for HOMA-IR) ( 30369944) Migraine ( 21448238) Peripheral artery disease ( 25009551)	Alzheimer disease and age of onset ( 26830138) Carotid plaque burden ( 28282560) Chronotype ( 26955885) Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Macular thickness ( 30535121) Major depressive disorder ( 29317602) Medication use (calcium channel blockers) ( 31015401) Morning vs. evening chronotype ( 26955885) Obesity ( 21552555) PR interval ( 30046033 32439900) Urinary albumin-to-creatinine ratio ( 31630189)
Interacting Genes		6 interacting genes: FAM25A FAM25C FAM25G FAT1 MYOC UBQLN2	12 interacting genes: CLK1 ENAH HOMER1 HOMER3 IGLL1 MT-ND1 NOXA1 SORBS2 TRAF4 TRIM14 UBC VASP
Entrez ID		3543	2195
HPRD ID		00905	02986
Ensembl ID		ENSG00000128322	ENSG00000083857
Uniprot IDs		P15814	Q14517
PDB IDs		2H32 2H3N 2LKQ
Enriched GO Terms of Interacting Partners?
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