IGFBP4 and PAPPA

Data Source:
HPRD (in vitro)

		IGFBP4	PAPPA
Description		insulin like growth factor binding protein 4	pappalysin 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen	Extracellular Region Extracellular Space
	Molecular Function	Signaling Receptor Binding Protein Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding	Metalloendopeptidase Activity Protein Binding Metallopeptidase Activity Zinc Ion Binding
	Biological Process	Regulation Of Cell Growth Inflammatory Response Signal Transduction Regulation Of Glucose Metabolic Process Positive Regulation Of MAPK Cascade Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Post-translational Protein Modification Cellular Protein Metabolic Process Type B Pancreatic Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway	Proteolysis Female Pregnancy Response To Follicle-stimulating Hormone Cellular Protein Metabolic Process Response To Glucocorticoid
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Drugs			Phenethyl Isothiocyanate
Diseases
GWAS		Height ( 23563607 31562340) Pancreatic cancer ( 29422604) Pancreatic ductal adenocarcinoma ( 30541042)	Birth weight ( 31043758) Brain morphology (MOSTest) ( 32665545) Conotruncal heart defects ( 24800985) Heel bone mineral density ( 28869591) Height ( 28552196 20881960 18391950) Metabolite levels ( 23823483) Pulse pressure ( 30224653)
Interacting Genes		8 interacting genes: CTSD HK3 IGF1 IGF2 KDM1A PAPPA SUV39H1 TF	10 interacting genes: ATF7IP C3 IGFBP4 PLG PRG2 SKIL SMAD2 SMAD3 SMAD9 TNNI3
Entrez ID		3487	5069
HPRD ID		00900	01448
Ensembl ID		ENSG00000141753	ENSG00000182752
Uniprot IDs		A0A024R1U8 P22692	B4DTA8 Q13219 Q7Z613
PDB IDs		1WQJ 2DSP 2DSQ 2DSR
Enriched GO Terms of Interacting Partners?
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