IGFBP4 and MX2

Data Source:
BioGRID (affinity chromatography technology)

		IGFBP4	MX2
Description		insulin like growth factor binding protein 4	MX dynamin like GTPase 2
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen	Nucleus Nuclear Pore Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Microtubule Cytoskeleton Membrane Axon Cytoplasmic Vesicle Mitochondrial Membrane Dendritic Spine Head Presynapse Postsynaptic Endocytic Zone Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding	GTPase Activity Protein Binding GTP Binding Microtubule Binding
	Biological Process	Regulation Of Cell Growth Inflammatory Response Signal Transduction Regulation Of Glucose Metabolic Process Positive Regulation Of MAPK Cascade Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Post-translational Protein Modification Cellular Protein Metabolic Process Type B Pancreatic Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway	Mitochondrial Fission Dynamin Family Protein Polymerization Involved In Mitochondrial Fission Defense Response Response To Virus Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Receptor Internalization Response To Interferon-alpha Regulation Of Nucleocytoplasmic Transport Regulation Of Synapse Structure Or Activity MRNA Transport Defense Response To Virus Regulation Of Cell Cycle Type I Interferon Signaling Pathway Membrane Fusion Postsynaptic Neurotransmitter Receptor Internalization
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	ISG15 antiviral mechanism Interferon alpha/beta signaling
Drugs
Diseases
GWAS		Height ( 23563607 31562340) Pancreatic cancer ( 29422604) Pancreatic ductal adenocarcinoma ( 30541042)	Cutaneous malignant melanoma ( 32341527) Melanoma ( 21983787 28212542) Nevus count or cutaneous melanoma ( 32341527 30429480) Parkinson disease and lewy body pathology ( 25663231)
Interacting Genes		8 interacting genes: CTSD HK3 IGF1 IGF2 KDM1A PAPPA SUV39H1 TF	3 interacting genes: ATRIP EHMT2 PIAS2
Entrez ID		3487	4600
HPRD ID		00900	01001
Ensembl ID		ENSG00000141753	ENSG00000183486
Uniprot IDs		A0A024R1U8 P22692	P20592
PDB IDs		1WQJ 2DSP 2DSQ 2DSR	4WHJ 4X0R 5UOT
Enriched GO Terms of Interacting Partners?
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