IGFBP3 and COL1A1

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		IGFBP3	COL1A1
Description		insulin like growth factor binding protein 3	collagen type I alpha 1 chain
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Endoplasmic Reticulum Lumen Insulin-like Growth Factor Binding Protein Complex Insulin-like Growth Factor Ternary Complex	Extracellular Region Collagen Type I Trimer Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Golgi Apparatus Secretory Granule Extracellular Matrix Collagen-containing Extracellular Matrix
	Molecular Function	Fibronectin Binding Protein Binding Insulin-like Growth Factor Binding Protein Tyrosine Phosphatase Activator Activity Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding Metal Ion Binding	Protease Binding Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Identical Protein Binding Metal Ion Binding Platelet-derived Growth Factor Binding
	Biological Process	Regulation Of Cell Growth Osteoblast Differentiation Negative Regulation Of Protein Phosphorylation Protein Phosphorylation Apoptotic Process Negative Regulation Of Cell Population Proliferation Negative Regulation Of Signal Transduction Regulation Of Glucose Metabolic Process Negative Regulation Of Smooth Muscle Cell Migration Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Phosphoprotein Phosphatase Activity Post-translational Protein Modification Cellular Protein Metabolic Process Type B Pancreatic Cell Proliferation Positive Regulation Of Myoblast Differentiation Negative Regulation Of Smooth Muscle Cell Proliferation	Skeletal System Development Ossification Blood Vessel Development Osteoblast Differentiation Intramembranous Ossification Endochondral Ossification Blood Coagulation Visual Perception Sensory Perception Of Sound Response To Mechanical Stimulus Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Cell-substrate Adhesion Protein Transport Platelet Activation Extracellular Matrix Organization Collagen Fibril Organization Positive Regulation Of Cell Migration Response To Corticosteroid Response To Estradiol Collagen Biosynthetic Process Protein Localization To Nucleus Tooth Mineralization Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Response To Drug Response To Hydrogen Peroxide Response To Peptide Hormone Skin Development Skin Morphogenesis Cellular Response To Fibroblast Growth Factor Stimulus Tooth Eruption Positive Regulation Of Transcription, DNA-templated Embryonic Skeletal System Development Regulation Of Immune Response Leukocyte Migration Response To CAMP Response To Hyperoxia Face Morphogenesis Bone Trabecula Formation Cartilage Development Involved In Endochondral Bone Morphogenesis Cellular Response To Amino Acid Stimulus Cellular Response To Mechanical Stimulus Cellular Response To Retinoic Acid Cellular Response To Vitamin E Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Fluoride
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) TP53 Regulates Transcription of Death Receptors and Ligands Post-translational protein phosphorylation	GPVI-mediated activation cascade Collagen degradation Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Assembly of collagen fibrils and other multimeric structures Cell surface interactions at the vascular wall Integrin cell surface interactions Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Syndecan interactions Non-integrin membrane-ECM interactions ECM proteoglycans ECM proteoglycans Scavenging by Class A Receptors GP1b-IX-V activation signalling Platelet Adhesion to exposed collagen Platelet Adhesion to exposed collagen Platelet Aggregation (Plug Formation) MET activates PTK2 signaling RUNX2 regulates osteoblast differentiation Collagen chain trimerization
Drugs		Alitretinoin Mecasermin	Collagenase clostridium histolyticum Halofuginone Clove oil Vonicog Alfa Von Willebrand Factor Human
Diseases			Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3); EDS vascular type (EDS4); EDS kyphoscoliosis type (EDS6); EDS arthrochalasia type (EDS7A/7B); EDS dermatospraxis type (EDS7C); EDS autosomal recessive cardiac valvular form (EDSCV); EDS musculocontractural type (EDSMC); EDS progeroid form (EDSP); Tenascin-X deficiency (TNXD); Brittle cornea syndrome (EDS6B); EDS-like spondylocheiro dysplasia (SCD-EDS) Infantile cortical hyperostosis; Caffey disease Osteogenesis imperfecta
GWAS		Birth weight ( 31043758) Blood pressure traits (multi-trait analysis) ( 28498854) Blood protein levels ( 30072576 29875488 23696881) Cataracts (operation) ( 31816047) Diastolic blood pressure ( 27841878 28498854 30578418) FEV1 ( 30804560) Height ( 25282103 31562340) Hypospadias ( 25108383) Insulin-like growth factors ( 21216879) Lung function (FVC) ( 30804560) Macular thickness ( 30535121) Major depressive disorder ( 23377640) Male-pattern baldness ( 27182965) Molybdenum levels ( 26025379) Night sleep phenotypes ( 27126917) Offspring birth weight ( 31043758) Poor prognosis in Crohn's disease ( 28067912) Pulse pressure ( 26390057 28135244 27841878 29403010 28739976 27618448 28498854 30487518) QRS duration ( 27577874 21076409) Rosacea symptom severity ( 29771307) Sitting height ratio ( 25865494) Subjective response to lithium treatment in bipolar disorder ( 26503763) Systolic blood pressure ( 27841878 27618447 27618448) Tonsillectomy ( 27182965 28928442) Venous thromboembolism ( 26888256)	Blood cell traits (multivariate analysis) ( 31080455) Breast cancer ( 17903305) Heel bone mineral density ( 30598549) Response to taxane treatment (docetaxel) ( 23006423)
Interacting Genes		38 interacting genes: ADAM12 AURKA BMPR1A BUB1 CAV1 CCND1 CD44 COL1A1 CSNK2A1 CTSD CTSG CTSL F2 FBXW7 FN1 GPI GTF3C1 IGF1 IGF1R IGF2 IGFALS KLK3 KLKB1 KPNB1 KRAS LTBP1 MLH3 MMP1 MMP2 MMP3 PAPPA2 PLG POLA2 PPARG RAD54B RXRA STK11 TF	40 interacting genes: ATP13A2 BARD1 BGN BMP1 BRCA1 CAPN1 CD36 CD44 CD93 CDC42 COL7A1 DCN DDR2 FGF7 FN1 HTRA1 IGFBP3 ITGA2 ITGA5 KEAP1 MAG MATN2 MCPH1 MMP2 MMP9 NID1 NID2 P4HB PAK1 PDGFA PDGFB PKD1 PRELP SPARC TGFBI THBS1 TMPRSS6 TXN UBC VWF
Entrez ID		3486	1277
HPRD ID		00899	00362
Ensembl ID		ENSG00000146674	ENSG00000108821
Uniprot IDs		B3KPF0 P17936	P02452
PDB IDs			1Q7D 2LLP 3EJH 3GXE 5CTD 5CTI 5CVA 5CVB 5K31 5OU8 5OU9
Enriched GO Terms of Interacting Partners?
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