IFNGR2 and TMEM254

Data Source:
BioGRID (two hybrid)

		IFNGR2	TMEM254
Description		interferon gamma receptor 2	transmembrane protein 254
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Cytoplasmic Vesicle Membrane	Integral Component Of Membrane
	Molecular Function	Cytokine Receptor Activity Interferon-gamma Receptor Activity Protein Binding	Protein Binding
	Biological Process	Cell Surface Receptor Signaling Pathway Response To Virus Cytokine-mediated Signaling Pathway Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway
Pathways		Interferon gamma signaling Regulation of IFNG signaling Regulation of IFNG signaling Potential therapeutics for SARS
Drugs		Interferon gamma-1b
Diseases		Tuberculosis IFN-gamma/IL-12 axis, including the following five diseases: IL-12 p40 subunit deficiency; IL-12 receptor (IL-12R) beta1 chain deficiency; IFN-gamma receptor (IFN gamma R) alpha chain deficiency; IFN-gamma receptor (IFN gamma R) beta chain deficiency; STAT-1 deficiency
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908 22936669 23128233) Diverticular disease ( 30177863) Educational attainment ( 25201988) Inflammatory bowel disease ( 28067908) Multiple sclerosis ( 31604244 24076602) Obesity-related traits ( 23251661) Psoriasis ( 25854761) Rheumatoid arthritis ( 30423114 24390342)
Interacting Genes		42 interacting genes: ADIPOQ ANXA5 BNIP3 BRICD5 BTNL8 CAMK2D CD302 CLDN19 CLEC7A CXCL9 DNAJA3 EMP3 ENTPD3 ERMP1 GIMAP5 IFNG IFNGR1 INSIG2 JAGN1 JAK2 NR3C1 PMP22 RPL37A RTP2 SEC22B SFT2D2 SFTPC SLC52A1 SMIM3 STRIT1 TMEM120B TMEM140 TMEM199 TMEM218 TMEM254 TMEM60 TMEM97 TRARG1 TREX1 TSPAN2 UNC50 ZDHHC24	41 interacting genes: AQP6 ARL13B ATP6V0E1 BCL2L13 BIK CD74 CD79A CERS4 CPLX4 EBP ELOVL4 FAM209A FKBP8 FNDC9 GPR152 GPX8 IFNGR2 IL3RA LEUTX LHFPL5 MFF MMGT1 MTIF3 PAGE1 PLP1 REEP4 RETREG3 SAR1A SEC11C SLC16A2 STOM STX1A SYT1 TMED8 TMEM14B TMEM237 TMEM31 TMEM45B TMEM51 TMEM79 TMX2
Entrez ID		3460	80195
HPRD ID		00956	08501
Ensembl ID		ENSG00000159128	ENSG00000133678
Uniprot IDs		A8K881 E7EUY1 P38484	A0A087WZM8 B4DU43 Q8TBM7
PDB IDs		5EH1 6E3K 6E3L
Enriched GO Terms of Interacting Partners?
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