IRGM and ATG10

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		IRGM	ATG10
Description		immunity related GTPase M	autophagy related 10
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Autophagosome Membrane Phagocytic Cup Mitochondrion Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Phagocytic Vesicle Membrane Cell Projection	Cytosol
	Molecular Function	GTPase Activity Protein Binding GTP Binding Protein Kinase Binding Protein Serine/threonine Kinase Activator Activity CARD Domain Binding BH3 Domain Binding	Protein Binding Atg12 Transferase Activity
	Biological Process	Autophagosome Assembly Positive Regulation Of Protein Phosphorylation Defense Response Inflammatory Response Positive Regulation Of Autophagy Positive Regulation Of Peptidyl-threonine Phosphorylation Protein Destabilization Positive Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Interferon-beta Defense Response To Bacterium Regulation Of Protein-containing Complex Assembly Innate Immune Response Protein Stabilization Defense Response To Gram-negative Bacterium Positive Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Protein Complex Stability Protein Lipidation Involved In Autophagosome Assembly CAMKK-AMPK Signaling Cascade Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Response To Lipopolysaccharide Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation By Symbiont Of Host Autophagy Cellular Response To Virus Positive Regulation Of Autophagosome Maturation	Protein Lipidation Autophagy ER Overload Response Protein Transport Macroautophagy Protein Phosphopantetheinylation Positive Regulation Of Protein Modification Process Protein Modification By Small Protein Conjugation
Pathways			Macroautophagy Macroautophagy
Drugs
Diseases
GWAS		Cholangiocarcinoma in primary sclerosing cholangitis ( 28779025) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 18587394 28067908 17554261 17554300 21102463) Dimensional psychopathology (Arousal) ( 29496196) Inflammatory bowel disease ( 28067908 23128233)	Adventurousness ( 30643258) Airway imaging phenotypes ( 26030696) Breast cancer ( 25751625 29059683) Carotid intima media thickness (mean) ( 31801372) General risk tolerance (MTAG) ( 30643258)
Interacting Genes		5 interacting genes: ATG10 ATG5 MAP1LC3C NOD2 SH3GLB1	4 interacting genes: ATG12 ATG5 ATG7 IRGM
Entrez ID		345611	83734
HPRD ID		19559	16497
Ensembl ID		ENSG00000237693	ENSG00000152348
Uniprot IDs		A1A4Y4	Q9H0Y0
PDB IDs
Enriched GO Terms of Interacting Partners?
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