IFNAR2 and HLCS

Data Source:
BioGRID (affinity chromatography technology)

		IFNAR2	HLCS
Description		interferon alpha and beta receptor subunit 2	holocarboxylase synthetase
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane	Chromatin Nuclear Lamina Cytoplasm Mitochondrion Cytosol Nuclear Matrix
	Molecular Function	Cytokine Receptor Activity Type I Interferon Receptor Activity Protein Binding Protein Kinase Binding	Biotin-[acetyl-CoA-carboxylase] Ligase Activity Biotin-[methylcrotonoyl-CoA-carboxylase] Ligase Activity Biotin-[methylmalonyl-CoA-carboxytransferase] Ligase Activity Biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] Ligase Activity Protein Binding ATP Binding Biotin Binding Biotin-protein Ligase Activity Enzyme Binding
	Biological Process	Cell Surface Receptor Signaling Pathway Receptor Signaling Pathway Via JAK-STAT Response To Virus Cytokine-mediated Signaling Pathway Response To Interferon-alpha Response To Interferon-beta Defense Response To Virus Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway	Biotin Metabolic Process Protein Biotinylation Histone Modification Protein Phosphopantetheinylation Response To Biotin Histone Biotinylation
Pathways			Biotin transport and metabolism Defective HLCS causes multiple carboxylase deficiency
Drugs		Peginterferon alfa-2a Interferon alfa-n1 Interferon alfa-n3 Peginterferon alfa-2b Interferon alfa-2a, Recombinant Interferon beta-1a Interferon beta-1b Interferon alfacon-1 Interferon alfa-2b Human interferon omega-1 Nylidrin	Biotin
Diseases			Holocarboxylase synthetase deficiency
GWAS		Attention deficit hyperactivity disorder ( 30563984) Cerebellum white matter volume ( 31530798) Crohn's disease ( 23128233) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Type 2 diabetes ( 30130595)	Developmental language disorder ( 27016271) Developmental language disorder (linguistic errors) ( 27016271) Hematocrit ( 32888494) Hemoglobin ( 32888494) Intracranial aneurysm ( 29531279) Night sleep phenotypes ( 27126917) Red blood cell count ( 32888494) Seasonality and depression ( 30217971)
Interacting Genes		14 interacting genes: IFNA2 IFNA5 IFNA8 IFNAR1 IFNB1 JAK1 PPP1R3B PRKCB RACK1 STAT1 STAT2 STAT3 TYK2 USP18	8 interacting genes: ACACB ANKRD29 DDX52 KRTAP5-9 MED19 POT1 SNX27 SPATA46
Entrez ID		3455	3141
HPRD ID		03850	08360
Ensembl ID		ENSG00000159110	ENSG00000159267
Uniprot IDs		P48551 Q9BUA0	P50747
PDB IDs		1N6U 1N6V 2HYM 2KZ1 2LAG 3S8W 3S9D 3SE3 3SE4
Enriched GO Terms of Interacting Partners?
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