APOC2 and RSAD2

Data Source:
BioGRID (two hybrid)

		APOC2	RSAD2
Description		apolipoprotein C2	radical S-adenosyl methionine domain containing 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Early Endosome Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle Intermediate-density Lipoprotein Particle Spherical High-density Lipoprotein Particle Chylomicron	Fibrillar Center Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Lipid Droplet
	Molecular Function	Protein Binding Lipid Binding Phospholipase Activator Activity Phospholipase Binding Lipase Inhibitor Activity Lipoprotein Lipase Activator Activity	Catalytic Activity Protein Binding Protein Self-association Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Retinoid Metabolic Process Positive Regulation Of Phospholipase Activity Positive Regulation Of Triglyceride Catabolic Process Positive Regulation Of Very-low-density Lipoprotein Particle Remodeling Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Lipid Catabolic Process Negative Regulation Of Cholesterol Transport Cholesterol Efflux Phospholipid Efflux Triglyceride-rich Lipoprotein Particle Remodeling Chylomicron Remodeling Very-low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Chylomicron Assembly Chylomicron Remnant Clearance High-density Lipoprotein Particle Clearance Cholesterol Homeostasis Negative Regulation Of Catalytic Activity Reverse Cholesterol Transport Positive Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Lipid Metabolic Process Negative Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Lipoprotein Lipase Activity Positive Regulation Of Phospholipid Catabolic Process Triglyceride Homeostasis	Response To Virus Viral Process Positive Regulation Of Toll-like Receptor 7 Signaling Pathway Positive Regulation Of Toll-like Receptor 9 Signaling Pathway CD4-positive, Alpha-beta T Cell Activation CD4-positive, Alpha-beta T Cell Differentiation Negative Regulation Of Viral Genome Replication Negative Regulation Of Protein Secretion Positive Regulation Of Immune Response Defense Response To Virus Type I Interferon Signaling Pathway Positive Regulation Of T-helper 2 Cell Cytokine Production
Pathways		Chylomicron assembly Assembly of active LPL and LIPC lipase complexes Chylomicron remodeling HDL remodeling NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux Retinoid metabolism and transport Retinoid metabolism and transport	Interferon alpha/beta signaling
Drugs		Copper
Diseases		Hyperlipoproteinemia, type I
GWAS		Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Blood protein levels ( 28240269) Carotid intima media thickness (maximum) ( 31801372) Carotid intima media thickness (mean) ( 31801372) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321) Cerebrospinal AB1-42 levels in mild cognitive impairment ( 29274321) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Cerebrospinal fluid AB1-42 levels ( 29274321) Cerebrospinal fluid p-tau levels ( 29274321) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid t-tau levels ( 29274321) Cerebrospinal fluid t-tau levels in mild cognitive impairment ( 29274321) Cholesterol, total ( 20686565) HDL cholesterol ( 20686565) HDL cholesterol levels ( 28334899) Hippocampal volume ( 29274321) Hippocampal volume in Alzheimer's disease dementia ( 29274321) LDL cholesterol ( 18802019 18193044 20864672 19060906 20686565) LDL cholesterol levels ( 28334899) Lipid metabolism phenotypes ( 22286219) Logical memory (delayed recall) ( 29274321) Logical memory (immediate recall) ( 29274321) Low density lipoprotein cholesterol levels ( 28548082) Quantitative traits ( 19197348) Total cholesterol levels ( 28334899 28548082) Triglyceride levels ( 28334899) Triglycerides ( 20686565) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)
Interacting Genes		26 interacting genes: APOL2 BCL2L2 CRYAB DIABLO GAD2 GSDMA IFI27 LETMD1 LPL MAIP1 MICOS10 MICOS13 NFU1 PORCN RSAD2 SENP2 SNAP47 SYT16 TBC1D20 THBD TIMMDC1 TMEM14B TPRG1 TTPA UBQLN1 UBQLN2	6 interacting genes: APOC1 APOC2 APOC4 RHBDD2 UBE2D1 UBE4A
Entrez ID		344	91543
HPRD ID		07457	07423
Ensembl ID		ENSG00000234906	ENSG00000134321
Uniprot IDs		A0A024R0T9 P02655	Q8WXG1
PDB IDs		1BY6 1I5J 1O8T 1SOH
Enriched GO Terms of Interacting Partners?
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