ATXN1L and ACO2

Data Source:
BioGRID (two hybrid)

		ATXN1L	ACO2
Description		ataxin 1 like	aconitase 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Dendrite	Mitochondrion Mitochondrial Matrix Cytosol
	Molecular Function	DNA Binding RNA Binding Protein Binding	Aconitate Hydratase Activity Iron Ion Binding Citrate Dehydratase Activity 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Brain Development Learning Memory Extracellular Matrix Organization Social Behavior Lung Alveolus Development Anatomical Structure Development Positive Regulation Of Hematopoietic Stem Cell Proliferation	Generation Of Precursor Metabolites And Energy Tricarboxylic Acid Cycle Citrate Metabolic Process
Pathways			Mitochondrial protein import Citric acid cycle (TCA cycle)
Drugs			Isocitric Acid 4-Hydroxy-Aconitate Ion Alpha-Methylisocitric Acid Aconitate Ion Tricarballylic acid
Diseases
GWAS		High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Response to anti-TNF therapy in rheumatoid arthritis ( 26776603) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Adult body size ( 32376654) Asthma ( 32296059) Meat-related diet ( 32066663) Neuroticism ( 29255261) Refractive error ( 32231278)
Interacting Genes		83 interacting genes: ACO2 ACOT7 ADORA1 AFAP1L2 AGXT ALG13 ANKHD1 AP1G2 AP2M1 APBB1 ARID5A ATXN1 C1orf94 CAMSAP2 CBFA2T2 CDSN CHD6 COIL CTBP1 DAB2 DAZAP2 EPB41L2 EPB41L3 FADS2 FAM168A FOXH1 FUS GAS7 GMEB2 GORASP2 GPATCH8 HGS HIVEP1 HLX HSFX1 KRTAP11-1 KRTAP13-1 KRTAP19-7 KRTAP21-2 KRTAP8-1 LARP4B MACROH2A1 MATN2 MBD1 MBD6 MEIS3 MEOX2 METTL17 METTL27 MYOZ3 NBR1 NCOR1 NCOR2 NIT1 NUTM2F PHPT1 PICALM PICK1 PRRC2B RAD54L2 RBFOX1 RBFOX2 RRAGC SCAF11 SHISA2 SMARCC2 SREBF1 ST6GALNAC6 STAC2 SUGP2 TBX2 TEX37 THY1 TMEM25 TMEM8B TRIP11 UNKL USP54 YPEL3 YY1AP1 ZBTB32 ZC3H7B ZSWIM8	5 interacting genes: APP ATXN1L C5AR2 CDC42 SUMO4
Entrez ID		342371	50
HPRD ID		19555	00012
Ensembl ID		ENSG00000224470	ENSG00000100412
Uniprot IDs		P0C7T5	Q99798
PDB IDs
Enriched GO Terms of Interacting Partners?
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