IRF8 and IRF6

Data Source:
BioGRID (pull down, pull down)

		IRF8	IRF6
Description		interferon regulatory factor 8	interferon regulatory factor 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Cell Junction Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Plasmacytoid Dendritic Cell Differentiation Immune System Process Regulation Of Transcription By RNA Polymerase II Phagocytosis Autophagy Immune Response Myeloid Cell Differentiation Regulation Of Type I Interferon Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-12 Production Defense Response To Bacterium Defense Response To Protozoan Positive Regulation Of Transcription By RNA Polymerase II Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Interferon-gamma Dendritic Cell Differentiation	Immune System Process Regulation Of Transcription By RNA Polymerase II Cell Cycle Arrest Negative Regulation Of Cell Population Proliferation Keratinocyte Differentiation Keratinocyte Proliferation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Cell Development Roof Of Mouth Development Limb Development Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Mammary Gland Epithelial Cell Differentiation Cranial Skeletal System Development
Pathways		Interferon gamma signaling Interferon alpha/beta signaling	Interferon gamma signaling Interferon alpha/beta signaling
Drugs
Diseases			Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate IRF6-related disorders, including: Popliteal pterygium syndrome (PPS); Van der Woude syndrome (VWS)
GWAS		B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199) Chronic lymphocytic leukemia ( 21131588 28165464 26956414 24292274 23770605) Composite immunoglobulin trait (IgA/IgM) ( 28628107) Diabetic retinopathy ( 21441570) Gestational age at birth (maternal effect) ( 27490719) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol levels ( 32203549) Inflammatory bowel disease ( 23128233) Limited cutaneous systemic scleroderma ( 29293537) Lymphocyte percentage of white cells ( 32888494) Major depressive disorder ( 23857890) Monocyte count ( 23314186 28193307 29403010 27863252) Monocyte percentage of white cells ( 32888494 27863252) Multiple sclerosis ( 31604244 24076602 19525953 21833088) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494 27863252) PR interval ( 32439900) Primary biliary cirrhosis ( 22961000) Rheumatoid arthritis ( 30423114 22446963 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic lupus erythematosus ( 27399966 26663301 26502338 28714469 19838195) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 31672989 21779181) Systemic sclerosis (anti-centromere-positive) ( 29293537) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Thyroid autoantibody positivity (anti-thyroglobulin (TgAb) and/or anti-thyroid peroxidase (TPOAb) levels) ( 31794020) Ulcerative colitis ( 32072174 23511034)	Alopecia areata ( 25608926) Alzheimer's disease (APOE e4 interaction) ( 25778476) Cleft lip ( 20436469) Cleft lip with or without cleft palate ( 28054174) Crohn's disease ( 28067908) Drug-induced liver injury in interferon-beta-treated multiple sclerosis ( 30013178) Inflammatory bowel disease ( 28067908) Nonsyndromic cleft lip ( 31609978) Nonsyndromic cleft lip with cleft palate ( 28232668) Nonsyndromic cleft lip with or without cleft palate ( 25775280) Nonsyndromic cleft palate ( 31609978) Orofacial clefts ( 19270707 22863734 28054174) Systolic blood pressure ( 30224653)
Interacting Genes		12 interacting genes: COPS2 IRF1 IRF2 IRF6 NFKB1 RELA SMURF2 SPI1 TOP1 TRAF6 TRIM21 ZBTB17	4 interacting genes: IRF8 RFX3 TLX2 ZBTB3
Entrez ID		3394	3664
HPRD ID		03336	06227
Ensembl ID		ENSG00000140968	ENSG00000117595
Uniprot IDs		Q02556	G0Z349 O14896
PDB IDs
Enriched GO Terms of Interacting Partners?
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