ICAM4 and RHAG

Data Source:
HPRD (in vivo)

		ICAM4	RHAG
Description		intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)	Rh associated glycoprotein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane	Plasma Membrane Integral Component Of Plasma Membrane Membrane
	Molecular Function	Integrin Binding	Protein Binding Ammonium Transmembrane Transporter Activity Leak Channel Activity Ankyrin Binding Carbon Dioxide Transmembrane Transporter Activity
	Biological Process	Cell Adhesion Extracellular Matrix Organization Regulation Of Immune Response Cell-cell Adhesion	Cellular Ion Homeostasis Carbon Dioxide Transport Ammonium Transport Bicarbonate Transport Carbon Dioxide Transmembrane Transport Ammonium Transmembrane Transport Inorganic Cation Transmembrane Transport
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions	Erythrocytes take up carbon dioxide and release oxygen Erythrocytes take up oxygen and release carbon dioxide Rhesus glycoproteins mediate ammonium transport. Defective RHAG causes regulator type Rh-null hemolytic anemia (RHN)
Drugs
Diseases			Hereditary stomatocytosis (HSt); Dehydrated hereditary stomatocytosis (DHS); Overhydrated hereditary stomatocytosis (OHS); Familial pseudohyperkalemia (FP)
GWAS		Blood protein levels ( 30072576 28240269)	Alcohol dependence ( 26365420) Mean corpuscular hemoglobin concentration ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		13 interacting genes: CREB3 CYSRT1 ITGA4 ITGAM ITGAV ITGB1 ITGB2 KRT31 KRT34 MTUS2 NBPF19 NOTCH2NLA RHAG	11 interacting genes: ANK1 CD47 CREB3L3 ERGIC3 FAM209A GYPB ICAM4 LMNA SLC4A1 TEX29 UNC93A
Entrez ID		3386	6005
HPRD ID		00198	01582
Ensembl ID		ENSG00000105371	ENSG00000112077
Uniprot IDs		Q14773 U5U6P8	Q02094 Q96E98
PDB IDs
Enriched GO Terms of Interacting Partners?
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