APOB and CD36

Data Source:
BioGRID (pull down)

		APOB	CD36
Description		apolipoprotein B	CD36 molecule
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Early Endosome Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Lipid Droplet Cytosol Plasma Membrane Endosome Membrane Clathrin-coated Endocytic Vesicle Membrane Endosome Lumen Vesicle Lumen Mature Chylomicron Chylomicron Remnant Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle Intermediate-density Lipoprotein Particle High-density Lipoprotein Particle Chylomicron Neuronal Cell Body Lysosomal Lumen Intracellular Membrane-bounded Organelle Extracellular Exosome Endoplasmic Reticulum Exit Site Endocytic Vesicle Lumen	Extracellular Space Cytoplasm Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Caveola External Side Of Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Endocytic Vesicle Membrane Platelet Alpha Granule Membrane Brush Border Membrane Specific Granule Membrane Receptor Complex Membrane Raft Phagocytic Vesicle Cell Periphery
	Molecular Function	Protein Binding Phospholipid Binding Heparin Binding Lipase Binding Low-density Lipoprotein Particle Receptor Binding Cholesterol Transfer Activity	Amyloid-beta Binding Low-density Lipoprotein Particle Receptor Activity Scavenger Receptor Activity Long-chain Fatty Acid Transporter Activity Protein Binding High-density Lipoprotein Particle Binding Lipid Binding Short-chain Fatty Acid Transmembrane Transporter Activity Low-density Lipoprotein Particle Binding Toll-like Receptor Binding Protein-containing Complex Binding Transforming Growth Factor Beta Binding Thrombospondin Receptor Activity Lipoteichoic Acid Immune Receptor Activity Lipoprotein Particle Binding Oxidised Low-density Lipoprotein Particle Receptor Activity Oleate Transmembrane Transporter Activity
	Biological Process	Retinoid Metabolic Process In Utero Embryonic Development Toll-like Receptor Signaling Pathway Triglyceride Mobilization Receptor-mediated Endocytosis Spermatogenesis Nervous System Development Cholesterol Metabolic Process Fertilization Response To Virus Response To Carbohydrate Post-embryonic Development Response To Selenium Ion Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Lipid Storage Positive Regulation Of Cholesterol Storage Triglyceride Catabolic Process Cholesterol Transport Flagellated Sperm Motility Response To Estradiol Response To Lipopolysaccharide Cholesterol Efflux Chylomicron Remodeling Low-density Lipoprotein Particle Remodeling Chylomicron Assembly Very-low-density Lipoprotein Particle Assembly Chylomicron Remnant Clearance Low-density Lipoprotein Particle Clearance Very-low-density Lipoprotein Particle Clearance Lipoprotein Biosynthetic Process Lipoprotein Catabolic Process Cholesterol Homeostasis Lipoprotein Transport Post-translational Protein Modification Cellular Protein Metabolic Process Regulation Of Cholesterol Biosynthetic Process Artery Morphogenesis Leukocyte Migration Membrane Organization Cellular Response To Tumor Necrosis Factor Cellular Response To Prostaglandin Stimulus Intermembrane Lipid Transfer	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell-matrix Adhesion Toll-like Receptor Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Production Of Molecular Mediator Involved In Inflammatory Response Platelet Degranulation MyD88-dependent Toll-like Receptor Signaling Pathway Lipid Metabolic Process Fatty Acid Metabolic Process Receptor-mediated Endocytosis Phagocytosis, Recognition Phagocytosis, Engulfment Cell Adhesion Positive Regulation Of Cytosolic Calcium Ion Concentration Nitric Oxide Mediated Signal Transduction Blood Coagulation Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Storage Positive Regulation Of Cell Death Long-chain Fatty Acid Transport Long-chain Fatty Acid Import Across Plasma Membrane Short-chain Fatty Acid Transport Regulation Of Lipid Metabolic Process Cytokine-mediated Signaling Pathway Lipid Storage CGMP-mediated Signaling Positive Regulation Of Blood Coagulation Intestinal Cholesterol Absorption Cholesterol Transport Receptor Internalization Regulation Of Lipopolysaccharide-mediated Signaling Pathway Interleukin-1 Beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Response To Lipid Regulation Of Toll-like Receptor Signaling Pathway Triglyceride Transport Plasma Lipoprotein Particle Clearance Low-density Lipoprotein Particle Clearance Response To Stilbenoid Toll-like Receptor TLR6:TLR2 Signaling Pathway Negative Regulation Of Protein Import Into Nucleus Lipoprotein Transport Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Protein-containing Complex Assembly Apoptotic Cell Clearance Neutrophil Degranulation Long-chain Fatty Acid Import Into Cell Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Peptidyl-tyrosine Phosphorylation Defense Response To Gram-positive Bacterium Intestinal Absorption Sensory Perception Of Taste Positive Regulation Of NF-kappaB Transcription Factor Activity Low-density Lipoprotein Particle Mediated Signaling Positive Regulation Of Phagocytosis, Engulfment Positive Regulation Of Macrophage Cytokine Production Positive Regulation Of ERK1 And ERK2 Cascade Cholesterol Import Response To Fatty Acid Response To Linoleic Acid Cellular Response To Lipopolysaccharide Cellular Response To Lipoteichoic Acid Cellular Response To Low-density Lipoprotein Particle Stimulus Cellular Response To Hydroperoxide Cellular Response To Diacyl Bacterial Lipopeptide Energy Homeostasis Regulation Of Action Potential Positive Regulation Of Cold-induced Thermogenesis Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Oxidised Low-density Lipoprotein Particle Clearance Amyloid-beta Clearance By Cellular Catabolic Process Positive Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Cellular Response To Amyloid-beta Amyloid Fibril Formation Lipid Transport Across Blood-brain Barrier Regulation Of Removal Of Superoxide Radicals Positive Regulation Of Blood Microparticle Formation
Pathways		Cell surface interactions at the vascular wall Scavenging by Class B Receptors Scavenging by Class B Receptors Scavenging by Class A Receptors Scavenging by Class A Receptors Scavenging by Class F Receptors Scavenging by Class F Receptors Scavenging by Class H Receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Platelet sensitization by LDL Regulation of TLR by endogenous ligand Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDL assembly Post-translational protein phosphorylation Chylomicron assembly Chylomicron remodeling Chylomicron clearance Chylomicron clearance LDL clearance LDL clearance LDL remodeling VLDL clearance VLDL clearance Retinoid metabolism and transport Retinoid metabolism and transport	Platelet degranulation Cross-presentation of particulate exogenous antigens (phagosomes) ER-Phagosome pathway MyD88:MAL(TIRAP) cascade initiated on plasma membrane Toll Like Receptor TLR6:TLR2 Cascade PPARA activates gene expression Scavenging by Class B Receptors Scavenging by Class B Receptors Transcriptional regulation of white adipocyte differentiation Intracellular metabolism of fatty acids regulates insulin secretion MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation
Drugs		Zinc chloride Zinc sulfate, unspecified form
Diseases		Hypercholesterolemia, autosomal dominant; Hyperlipoproteinemia, type IIa
GWAS		Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Barrett's esophagus or Esophageal adenocarcinoma ( 31527586) Binge eating behaviour and bipolar disorder ( 24882193) Blood protein levels ( 29875488 28240269) Cardiovascular disease risk factors ( 21943158) Carotid intima media thickness ( 30510157) Cholesterol, total ( 24097068 19060911 25961943 20686565 26582766) Coronary artery disease ( 32469254 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Erectile dysfunction and prostate cancer treatment ( 20932654) Gastroesophageal reflux disease ( 31527586) HDL cholesterol ( 20864672 19060911 30275531 25961943 20686565) HDL cholesterol levels ( 32203549) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Hypertriglyceridemia ( 20657596) LDL (oxidized) ( 23247145) LDL cholesterol ( 18262040 23726366 24097068 24507774 21059979 18193043 18193044 20864672 19060906 19060910 19060911 30275531 21347282 25961943 26780889 20686565 26582766) LDL cholesterol levels ( 32203549 28334899 26690388 31087446 17463246 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lipid metabolism phenotypes ( 19936222) Lipid or lipoprotein levels ( 23696881) Lipoprotein-associated phospholipase A2 activity and mass ( 23118302) Low density lipoprotein cholesterol levels ( 31969989) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolic syndrome ( 22399527 31589552) Metabolic traits ( 19060910) Metabolite levels ( 22916037) Metabolite levels (lipoprotein measures) ( 27005778) Pancreatic cancer ( 30206226) Platelet count ( 32888494) Plateletcrit ( 32888494) Pulse pressure ( 30224653) Red cell distribution width ( 32888494) Response to statin therapy ( 20339536) Response to statins (LDL cholesterol change) ( 31969989) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Total cholesterol levels ( 30718733 28334899 26690388 31087446 30275531) Triglyceride levels ( 32203549 32154731 29403010) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglycerides ( 18193044 20864672 26160806 19060906 19060911 25961943 20686565)	Aspartate aminotransferase levels ( 29403010) Basophil count ( 32888494) Blood protein levels ( 30072576) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 32602732) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol ( 23726366 30275531) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Hemoglobin ( 32888494) High density lipoprotein cholesterol levels ( 29403010) Left ventricular mass ( 19454037) Mean corpuscular hemoglobin concentration ( 29403010) Mean corpuscular volume ( 32888494 27863252) Mean platelet volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Night sleep phenotypes ( 27126917) Platelet count ( 29403010 32888494 22423221 27863252) Plateletcrit ( 32888494) Red blood cell count ( 32888494 27863252) Red cell distribution width ( 32888494 28957414) Response to fenofibrate ( 22890011)
Interacting Genes		24 interacting genes: AKT2 APOA1 ARFGAP1 BGN CALR CANX CD36 HSP90AA1 HSP90B1 HSPA1A HSPA5 HSPA8 LDLR LIPC LRP2 LRP6 MTTP PDIA4 PPIB PRDX4 SEC61A2 SEC61B SMAD3 TREM2	19 interacting genes: APOB APP CD9 CHRD COL1A1 COL1A2 FYN HSD11B1 ITGA2B ITGA6 ITGB1 ITGB3 LDLR LYN MATK SRC THBS1 VLDLR YES1
Entrez ID		338	948
HPRD ID		00133	01430
Ensembl ID		ENSG00000084674	ENSG00000135218
Uniprot IDs		P04114 Q59HB3 Q7Z7Q0	A4D1B1 B7Z6C3 E9PLT1 P16671
PDB IDs			5LGD
Enriched GO Terms of Interacting Partners?
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