KRTAP6-1 and CAMK2G

Data Source:
BioGRID (two hybrid)

		KRTAP6-1	CAMK2G
Description		keratin associated protein 6-1	calcium/calmodulin dependent protein kinase II gamma
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Intermediate Filament	Nucleoplasm Cytoplasm Cytosol Calcium- And Calmodulin-dependent Protein Kinase Complex Membrane Endocytic Vesicle Membrane Sarcoplasmic Reticulum Membrane Neuron Projection
	Molecular Function	Protein Binding	Calmodulin-dependent Protein Kinase Activity Calcium-dependent Protein Serine/threonine Phosphatase Activity Protein Binding Calmodulin Binding ATP Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Keratinization	Protein Phosphorylation Protein Dephosphorylation Nervous System Development Regulation Of Neuron Projection Development Regulation Of Skeletal Muscle Adaptation Insulin Secretion Cell Differentiation Regulation Of Calcium Ion Transport Interferon-gamma-mediated Signaling Pathway Regulation Of Cellular Response To Heat
Pathways		Keratinization	CaMK IV-mediated phosphorylation of CREB HSF1-dependent transactivation Trafficking of AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Ras activation upon Ca2+ influx through NMDA receptor Phase 0 - rapid depolarisation Ion homeostasis RAF activation RAF/MAP kinase cascade Signaling by moderate kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Interferon gamma signaling Regulation of MECP2 expression and activity Ion transport by P-type ATPases Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs			Bosutinib 1-tert-butyl-3-(3-methylbenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Fostamatinib
Diseases
GWAS			Body size at age 10 ( 32376654) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Crohn's disease ( 28067908) FEV1 ( 30804560) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Multiple sclerosis ( 31604244) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Peak expiratory flow ( 30804560) Psoriasis ( 25939698) Psoriasis vulgaris ( 26626624) Systemic lupus erythematosus ( 28714469) Type 2 diabetes ( 30054458)
Interacting Genes		90 interacting genes: ANAPC11 APOBEC1 ARID5A BAHD1 BHLHE40 C11orf16 CAMK2A CAMK2G CATSPER1 CCDC120 CCDC187 CCDC24 CDA CELF5 CREB5 CRYAB CYSRT1 DAZAP2 DTX2 EFEMP1 EVX2 FCHO1 GLIS2 GLIS3 GNE GPS2 GRN HELT HEY2 HHEX HOXA1 HOXC8 ITIH6 KPRP KRTAP11-1 KRTAP12-1 KRTAP12-3 KRTAP26-1 KRTAP3-1 KRTAP4-5 KRTAP6-2 KRTAP6-3 LONRF1 MAGED1 MAPK1IP1L MED25 MEIS2 MGAT5B MYOZ3 NAF1 NOTO NTAQ1 OLIG3 OSR2 OTX1 P4HA3 PATZ1 PDIA2 PITX1 PITX2 PLSCR3 PLSCR4 POU1F1 POU4F2 PRR13 PRR35 RBPMS2 RHOXF2 SMARCC1 SMN1 SMN2 SNRPB TCF7L2 TEKT3 TENT5B TFAP2D TLX3 TNIP1 TOLLIP TRAPPC14 TRIP13 UNC5CL VAC14 VENTX VGLL3 VPS37C ZBTB32 ZC3H10 ZIC1 ZNF414	50 interacting genes: ACTN2 ACTN4 ADCY3 ATF1 CABP2 CALM1 CAMK2A CAMK2B CAMK2D CDC37 CHAT CREM DUS1L EGFR ESRRG FLNA GRIA1 GRIA4 GRIN1 GRIN2B KANK2 KRTAP19-3 KRTAP6-1 KRTAP6-3 LRRC7 MRPL11 MYLK NUTF2 NXF1 PEA15 PLCB3 PSMB1 PTEN RCHY1 RRAD RYR1 SMAD2 SMAD3 SMAD4 SPR STAT1 STMN1 STRBP SYN1 TH TIAM1 TNPO2 TNPO3 TTC5 UBE2I
Entrez ID		337966	818
HPRD ID		11218	03672
Ensembl ID		ENSG00000184724	ENSG00000148660
Uniprot IDs		Q3LI64	A0A2Q3DQE3 B3KY86 Q13280 Q13555 Q5SWX3
PDB IDs			2UX0 2V7O
Enriched GO Terms of Interacting Partners?
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