TNC and ASTN2

Data Source:
BioGRID (affinity chromatography technology)

		TNC	ASTN2
Description		tenascin C	astrotactin 2
Image
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Interstitial Matrix Extracellular Space Endoplasmic Reticulum Lumen Focal Adhesion Membrane Collagen-containing Extracellular Matrix Perisynaptic Extracellular Matrix	Endosome Early Endosome Late Endosome Cell Cortex Integral Component Of Membrane Clathrin-coated Vesicle Perikaryon Cell Pole
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Syndecan Binding	Calcium Ion Binding Inositol 1,3,4,5 Tetrakisphosphate Binding
	Biological Process	Osteoblast Differentiation Cell Adhesion Negative Regulation Of Cell Adhesion Neuromuscular Junction Development Positive Regulation Of Cell Population Proliferation Response To Wounding Response To Mechanical Stimulus Positive Regulation Of Gene Expression Peripheral Nervous System Axon Regeneration Extracellular Matrix Organization Wound Healing Odontogenesis Of Dentin-containing Tooth Post-translational Protein Modification Cellular Protein Metabolic Process Response To Ethanol Bud Outgrowth Involved In Lung Branching Mesenchymal-epithelial Cell Signaling Involved In Prostate Gland Development Prostate Gland Epithelium Morphogenesis Cellular Response To Retinoic Acid Cellular Response To Vitamin D Response To Fibroblast Growth Factor Cellular Response To Prostaglandin D Stimulus	Neuron Migration Neuron Cell-cell Adhesion Protein Transport Establishment Of Body Hair Planar Orientation Negative Regulation Of Protein Localization To Cell Surface
Pathways		Integrin cell surface interactions Syndecan interactions ECM proteoglycans Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases
GWAS		Adult body size ( 32376654) Blood protein levels ( 29875488 28240269) Developmental language disorder (syntactic complexity) ( 27016271) Inflammatory bowel disease ( 23128233) Metabolite levels ( 23823483) Mosquito bite size ( 28199695) Osteoarthritis (hip) ( 30374069) Response to bupropion and depression ( 27622933)	Adverse response to drug ( 30420678) Attention deficit hyperactivity disorder ( 18839057) Bipolar disorder and schizophrenia ( 20889312) Body mass index ( 28892062 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Brain morphology (MOSTest) ( 32665545) Breast cancer ( 29059683) Caudal middle frontal gyrus volume ( 31530798) Chronic obstructive pulmonary disease ( 30804561) Dentate gyrus granule cell layer volume ( 30279459) Depression ( 29700475) Economic and political preferences (fairness) ( 22566634) Estimated glomerular filtration rate ( 31152163 31451708 30604766) Estimated glomerular filtration rate in non-diabetics ( 31451708) Feeling guilty ( 29500382) FEV1 ( 30804560) Glomerular filtration rate (creatinine) ( 28452372) Glucose homeostasis traits ( 25524916) Headache ( 29397368) Heel bone mineral density ( 30598549) Height ( 31562340) Hip shape (DXA scan) ( 30320955) Hippocampal subfield CA4 volume ( 30279459) Hippocampal volume ( 22504421) Idiopathic osteonecrosis of the femoral head ( 28000841) Immune response to anthrax vaccine ( 22658931) Lifetime average cigarettes per day in chronic obstructive pulmonary disease ( 21685187) Lung function (FEV1/FVC) ( 28166213 26635082 30804560) Medication use (antimigraine preparations) ( 31015401) Metabolite levels ( 23823483) Migraine ( 22683712 27182965 27322543) Migraine - clinic-based ( 23793025) Migraine without aura ( 23793025 27322543) Multisite chronic pain ( 31194737) Nonunion in individuals with fractures ( 30680360) Obesity-related traits ( 23251661) Osteoarthritis (hip) ( 30664745 30374069) Peak expiratory flow ( 30804560) PR interval ( 32439900) Pulmonary function (smoking interaction) ( 23284291) Response to antipsychotic treatment ( 20195266) Subiculum volume ( 30279459) Survival in pancreatic cancer ( 28470677) Total hippocampal volume ( 30279459) Transverse temporal cortex volume ( 31530798)
Interacting Genes		6 interacting genes: CNTN1 EGFR FN1 ITGA5 NCAN PTPRB	1 interacting genes: CHRM5
Entrez ID		3371	23245
HPRD ID		01756	12498
Ensembl ID		ENSG00000041982	ENSG00000148219
Uniprot IDs		B4E1W8 J3QSU6 P24821 Q4LE33	B3KN99 B7ZKP4 B7ZKP5 O75129 X6R5P2
PDB IDs		1TEN 2RB8 2RBL 6BRB 6QNV	5J67 5J68 5J69
Enriched GO Terms of Interacting Partners?
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