HTR2A and MRPL28

Data Source:
HPRD (two hybrid)

		HTR2A	MRPL28
Description		5-hydroxytryptamine receptor 2A	mitochondrial ribosomal protein L28
Image
GO Annotations	Cellular Component	Cytosol Plasma Membrane Integral Component Of Plasma Membrane Caveola Axon Dendrite Cytoplasmic Vesicle Neuronal Cell Body Dendritic Shaft Cell Body Fiber G Protein-coupled Serotonin Receptor Complex Glutamatergic Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Membrane	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Ribosome Mitochondrial Large Ribosomal Subunit Cytosol
	Molecular Function	Gq/11-coupled Serotonin Receptor Activity Virus Receptor Activity G-protein Alpha-subunit Binding G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity Identical Protein Binding Protein-containing Complex Binding Serotonin Binding 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine Binding	RNA Binding Structural Constituent Of Ribosome Protein Binding
	Biological Process	Temperature Homeostasis Cellular Calcium Ion Homeostasis G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Phospholipase C-activating Serotonin Receptor Signaling Pathway Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Aging Memory Cell Death Positive Regulation Of Cell Population Proliferation Positive Regulation Of Phosphatidylinositol Biosynthetic Process Regulation Of Dopamine Secretion Phosphatidylinositol 3-kinase Signaling Artery Smooth Muscle Contraction Urinary Bladder Smooth Muscle Contraction Sleep Response To Drug Negative Regulation Of Potassium Ion Transport Positive Regulation Of MAP Kinase Activity Protein Localization To Cytoskeleton Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Glycolytic Process Positive Regulation Of Vasoconstriction Viral Entry Into Host Cell Behavioral Response To Cocaine Positive Regulation Of Peptidyl-tyrosine Phosphorylation Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of ERK1 And ERK2 Cascade G Protein-coupled Serotonin Receptor Signaling Pathway Regulation Of Synaptic Vesicle Exocytosis	Translation Mitochondrial Translational Elongation Mitochondrial Translational Termination
Pathways		Serotonin receptors G alpha (q) signalling events	Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination
Drugs		Ziprasidone Methysergide Cabergoline Zolmitriptan Amitriptyline Olanzapine Clozapine Mirtazapine Loxapine Remoxipride Promazine Cyproheptadine Imipramine Chlorpromazine Chlorpromazine Haloperidol Nortriptyline Amoxapine Lamotrigine Fenfluramine Lisuride Cisapride Fluphenazine Trazodone Thioridazine Ergotamine Apomorphine Paroxetine Paroxetine Trimipramine Risperidone Epinastine Propiomazine Minaprine Donepezil Flupentixol Cyclobenzaprine Mesoridazine Maprotiline Ergoloid mesylate Tegaserod Doxepin Nefazodone Desipramine Escitalopram Pergolide Bromocriptine Ketamine Quetiapine Aripiprazole Chlorprothixene Chlorprothixene Clomipramine Paliperidone Yohimbine Methotrimeprazine MMDA Midomafetamine Dimethyltryptamine 4-Bromo-2,5-dimethoxyphenethylamine Acepromazine Molindone Pipotiazine Thioproperazine Thiothixene Zuclopenthixol Aniracetam Fluspirilene Flibanserin Iloperidone HY10275 APD791 Pimavanserin Epicept NP-1 BL-1020 Cariprazine Lumateperone YKP-1358 Sertindole Mianserin Pizotifen Asenapine Ocaperidone Amisulpride Dotarizine Deramciclane Esmirtazapine Cinitapride Lurasidone Serotonin Perospirone Amperozide Butriptyline Cannabidiol Brexpiprazole Dosulepin Etoperidone Lorpiprazole Blonanserin Zotepine Pipamperone Setiptiline Dihydroergocornine Gilteritinib Sarpogrelate Eplivanserin Ketanserin Nelotanserin Ritanserin Tiapride Dihydroergocristine 2,5-Dimethoxy-4-ethylthioamphetamine N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine Medical Cannabis 5-methoxy-N,N-dimethyltryptamine Nabiximols Aripiprazole lauroxil
Diseases
GWAS		Blood protein levels ( 28240269) Cardiac hypertrophy ( 21348951) Parkinson disease and lewy body pathology ( 25663231) Serum 25-Hydroxyvitamin D levels ( 29325163) SjÃ¶gren's syndrome ( 28076899) Subcutaneous adipose tissue ( 22589738)	Body mass index ( 26426971) Heel bone mineral density ( 28869591) Refractive error ( 32231278)
Interacting Genes		19 interacting genes: ANKS1B ARF1 ARF6 DLG1 DLG4 EIF3F GLUL GNA11 GNAI1 GNAQ JAK2 MAP1A MRPL28 NDUFB10 NME3 NTRK3 PON2 PPP5C RPS6KA3	28 interacting genes: ABI2 APP BANP CDCA7L CDR2 ENKD1 FAM9B HMBOX1 HSPB1 HTR2A IKZF3 LARP1B LENG1 LRRK2 NFKBID OXA1L PPL SCNM1 TEF TRAF3IP2 TRAF4 TSHZ3 TSSK3 TUBB3 UPP2 USP2 USP20 ZNF655
Entrez ID		3356	10573
HPRD ID		01638	06889
Ensembl ID		ENSG00000102468	ENSG00000086504
Uniprot IDs		P28223	Q13084
PDB IDs		6A93 6A94 6WGT 6WH4 6WHA	3J7Y 5OOL 5OOM 6I9R 6NU2 6NU3 6VLZ 6VMI 6ZS9 6ZSA 6ZSB 6ZSC 6ZSD 6ZSE 6ZSG
Enriched GO Terms of Interacting Partners?
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