HTR1B and HTR1D

Data Source:
HPRD (in vivo)

		HTR1B	HTR1D
Description		5-hydroxytryptamine receptor 1B	5-hydroxytryptamine receptor 1D
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Dendrite Calyx Of Held G Protein-coupled Serotonin Receptor Complex Integral Component Of Presynaptic Membrane Serotonergic Synapse	Plasma Membrane Integral Component Of Plasma Membrane Dendrite Synapse
	Molecular Function	G Protein-coupled Serotonin Receptor Activity Protein Binding Drug Binding Neurotransmitter Receptor Activity Serotonin Binding Voltage-gated Calcium Channel Activity Involved In Regulation Of Presynaptic Cytosolic Calcium Levels	G Protein-coupled Serotonin Receptor Activity Neurotransmitter Receptor Activity Serotonin Binding
	Biological Process	G Protein-coupled Receptor Internalization G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Chemical Synaptic Transmission Negative Regulation Of Gamma-aminobutyric Acid Secretion Regulation Of Dopamine Secretion Negative Regulation Of Serotonin Secretion Negative Regulation Of Synaptic Transmission, GABAergic Cellular Response To Drug Response To Cocaine Vasoconstriction Drinking Behavior Response To Ethanol Bone Remodeling Regulation Of Behavior Response To Mineralocorticoid Negative Regulation Of Synaptic Transmission, Glutamatergic Cellular Response To Alkaloid Cellular Response To Temperature Stimulus Presynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Regulation Of Synaptic Vesicle Exocytosis	G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Intestine Smooth Muscle Contraction Regulation Of Locomotion Vasoconstriction Regulation Of Behavior
Pathways		Serotonin receptors G alpha (i) signalling events	Serotonin receptors G alpha (i) signalling events
Drugs		Eletriptan Ziprasidone Methysergide Cabergoline Zolmitriptan Dihydroergotamine Amitriptyline Olanzapine Clozapine Loxapine Amoxapine Propranolol Lisuride Sumatriptan Ergotamine Apomorphine Paroxetine Ondansetron Almotriptan Naratriptan Rizatriptan Pindolol Frovatriptan Ergoloid mesylate Pergolide Bromocriptine Ketamine Quetiapine Aripiprazole Chlorprothixene Penbutolol Yohimbine Dapoxetine NXN-188 Pizotifen Asenapine Bopindolol Vortioxetine Setiptiline Dihydroergocornine Gilteritinib Tiapride Dihydroergocristine Aripiprazole lauroxil	Eletriptan Ziprasidone Cabergoline Zolmitriptan Dihydroergotamine Amitriptyline Olanzapine Clozapine Loxapine Fenfluramine Lisuride Sumatriptan Ergotamine Apomorphine Paroxetine Trimipramine Risperidone Almotriptan Naratriptan Rizatriptan Frovatriptan Ergoloid mesylate Pergolide Bromocriptine Ketamine Quetiapine Aripiprazole Chlorprothixene Paliperidone Yohimbine Lofexidine NXN-188 Pizotifen Setiptiline Dihydroergocornine Gilteritinib Tiapride Dihydroergocristine Aripiprazole lauroxil
Diseases
GWAS		Brain volume in infants (white matter) ( 28763065) Psychological distress ( 30705256) Response to fenofibrate (total cholesterol levels) ( 27002377)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Estimated glomerular filtration rate ( 31015462) Height ( 28552196 20881960) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		4 interacting genes: ACTN2 HTR1A HTR1D MDFI	3 interacting genes: HTR1A HTR1B S1PR1
Entrez ID		3351	3352
HPRD ID		01634	01636
Ensembl ID		ENSG00000135312	ENSG00000179546
Uniprot IDs		A8K215 P28222 X5D7I5	P28221
PDB IDs		2G1X 4IAQ 4IAR 5V54 6G79 7C61
Enriched GO Terms of Interacting Partners?
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