H3C15 and PADI4

Data Source:
BioGRID (enzymatic study)

		H3C15	PADI4
Description		H3 clustered histone 15	peptidyl arginine deiminase 4
Image
GO Annotations	Cellular Component	Nucleosome Extracellular Region Nucleus Nucleoplasm Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	DNA Binding Protein Binding Protein Heterodimerization Activity	Protein-arginine Deiminase Activity Calcium Ion Binding Protein Binding Arginine Binding Identical Protein Binding
	Biological Process	RDNA Heterochromatin Assembly Chromatin Organization Nucleosome Assembly Blood Coagulation Interleukin-7-mediated Signaling Pathway Cellular Protein Metabolic Process Regulation Of Megakaryocyte Differentiation Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Silencing By MiRNA	Chromatin Organization Nucleosome Assembly Chromatin Remodeling Cellular Protein Modification Process Protein Citrullination Stem Cell Population Maintenance Histone H3-R26 Citrullination Histone Citrullination Innate Immune Response
Pathways		Interleukin-7 signaling Interleukin-7 signaling Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) HDACs deacetylate histones PKMTs methylate histone lysines HDMs demethylate histones HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines Chromatin modifying enzymes SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Amyloid fiber formation Factors involved in megakaryocyte development and platelet production	Chromatin modifying enzymes
Drugs			Citrulline Azithromycin Tetracycline Streptomycin N-[(1S)-1-(aminocarbonyl)-4-(ethanimidoylamino)butyl]benzamide
Diseases
GWAS			Autoimmune traits (pleiotropy) ( 30572963) Basal cell carcinoma ( 18849993) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) IgA nephropathy ( 25305756) Rheumatoid arthritis ( 21452313 21505073 30423114 30572963 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676)
Interacting Genes		18 interacting genes: ANP32A CBX5 DNTTIP2 EHMT2 GTF3C4 HDAC9 KDM5A KDM5C LALBA MECP2 NASP PADI4 PRDM1 PRMT6 SETDB1 SUV39H1 UBR7 UHRF1	10 interacting genes: ANXA4 APP FBXO25 H3C15 HDAC2 LRRK2 NPM1 POU6F2 SMURF1 TRIB3
Entrez ID		333932	23569
HPRD ID			05635
Ensembl ID		ENSG00000203852	ENSG00000159339
Uniprot IDs		Q71DI3	Q9UM07
PDB IDs		2IIJ 2X4W 2X4X 2X4Y 3AV1 3DB3 3MO8 3QO2 3R93 4MZF 4MZG 4MZH 4OUC 5B0Y 5B0Z 5B40 5BO0 5CIU 5VAC 6ACE 6FML 6T79 6T7A 6T7B 6T7C 6T7D 6X59 6X5A 6XJD 6Y5D 6Y5E 7BQZ 7BU9 7JO9 7JOA	1WD8 1WD9 1WDA 2DEW 2DEX 2DEY 2DW5 3APM 3APN 3B1T 3B1U 4DKT 4X8C 4X8G 5N0M 5N0Y 5N0Z 5N1B
Enriched GO Terms of Interacting Partners?
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