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HSPA9 and IL4
Data Source:
BioGRID
(affinity chromatography technology)
HSPA9
IL4
Description
heat shock protein family A (Hsp70) member 9
interleukin 4
Image
GO Annotations
Cellular Component
SAM Complex
Nucleolus
Cytoplasm
Mitochondrion
Mitochondrial Matrix
Focal Adhesion
Mitochondrial Nucleoid
Extracellular Exosome
MIB Complex
Extracellular Region
Extracellular Space
Molecular Function
RNA Binding
Protein Binding
ATP Binding
ATPase Activity
Heat Shock Protein Binding
Ubiquitin Protein Ligase Binding
Protein Folding Chaperone
Unfolded Protein Binding
Misfolded Protein Binding
Cytokine Activity
Interleukin-4 Receptor Binding
Protein Binding
Growth Factor Activity
Biological Process
Protein Export From Nucleus
Inner Mitochondrial Membrane Organization
Iron-sulfur Cluster Assembly
Erythrocyte Differentiation
Cellular Response To Unfolded Protein
Interleukin-12-mediated Signaling Pathway
Protein Refolding
Negative Regulation Of Apoptotic Process
Regulation Of Erythrocyte Differentiation
Negative Regulation Of Erythrocyte Differentiation
Chaperone Cofactor-dependent Protein Refolding
Negative Regulation Of Hematopoietic Stem Cell Differentiation
Negative Regulation Of Hemopoiesis
Negative Regulation Of Transcription By RNA Polymerase II
Microglial Cell Activation
Innate Immune Response In Mucosa
Positive Regulation Of Defense Response To Virus By Host
Negative Regulation Of Acute Inflammatory Response
Negative Regulation Of Chronic Inflammatory Response
Immune Response
Cholesterol Metabolic Process
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Gene Expression
Negative Regulation Of Epithelial Cell Migration
Positive Regulation Of Macroautophagy
Cytokine-mediated Signaling Pathway
B Cell Differentiation
Positive Regulation Of Cell Migration
Positive Regulation Of B Cell Proliferation
B Cell Costimulation
Negative Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-13 Production
T-helper 2 Cell Cytokine Production
Type 2 Immune Response
Positive Regulation Of T Cell Proliferation
T Cell Activation
Macrophage Activation
Regulation Of Phosphorylation
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Activation Of Janus Kinase Activity
Myeloid Dendritic Cell Differentiation
Negative Regulation Of Macrophage Activation
Negative Regulation Of Apoptotic Process
Positive Regulation Of Mast Cell Degranulation
T-helper 2 Cell Differentiation
Regulation Of Isotype Switching
Positive Regulation Of MHC Class II Biosynthetic Process
Positive Regulation Of T Cell Differentiation
Negative Regulation Of Osteoclast Differentiation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Receptor-mediated Endocytosis
Positive Regulation Of Isotype Switching To IgE Isotypes
Positive Regulation Of Isotype Switching To IgG Isotypes
Negative Regulation Of Inflammatory Response
Regulation Of Immune Response
Positive Regulation Of Mononuclear Cell Migration
Dendritic Cell Differentiation
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Positive Regulation Of Cold-induced Thermogenesis
Neuroinflammatory Response
Negative Regulation Of Neuroinflammatory Response
Positive Regulation Of Amyloid-beta Clearance
Positive Regulation Of Myoblast Fusion
Positive Regulation Of Cellular Respiration
Negative Regulation Of Complement-dependent Cytotoxicity
Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus
Negative Regulation Of T-helper 17 Cell Differentiation
Negative Regulation Of Endothelial Cell Apoptotic Process
Positive Regulation Of Eosinophil Chemotaxis
Positive Regulation Of ATP Biosynthetic Process
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Mitochondrial protein import
Regulation of HSF1-mediated heat shock response
Cristae formation
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Interleukin-4 and Interleukin-13 signaling
Interleukin-18 signaling
Drugs
Pascolizumab
Diseases
Asthma
GWAS
Autism spectrum disorder or schizophrenia (
28540026
)
Cerebrospinal AB1-42 levels in Alzheimer's disease dementia (
29274321
)
Schizophrenia (
25056061
29483656
)
Asthma (
31959851
31619474
29273806
)
Asthma (childhood onset) (
31036433
29273806
)
Asthma or allergic disease (pleiotropy) (
29785011
)
Atopic dermatitis (
25574825
)
Atopic march (
26542096
)
Inflammatory bowel disease (
23128233
)
Psoriasis (
25574825
23143594
)
Psoriasis vulgaris (
26626624
)
Refractive error (
32231278
)
Interacting Genes
26 interacting genes:
APP
DNAJC19
DNLZ
ERBB2
ERCC6
FGF1
HSP90B1
HSPBP1
LAMTOR5
LINC01554
LSM8
MATK
MVD
NELFB
PTPN11
PTPRF
SIRPA
STUB1
SUMO2
SUMO4
SUPT6H
TIMM44
TP53
XPO1
YKT6
YWHAG
7 interacting genes:
A2M
CD53
FBXO7
IL13RA2
IL2RG
IL4R
PIK3CD
Entrez ID
3313
3565
HPRD ID
02770
00989
Ensembl ID
ENSG00000113013
ENSG00000113520
Uniprot IDs
A0A384P5G6
P38646
D4HNR6
P05112
Q5FC01
PDB IDs
3N8E
4KBO
6NHK
6P2U
6PMT
1BBN
1BCN
1CYL
1HIJ
1HIK
1HZI
1IAR
1ILL
1ITE
1ITI
1ITL
1ITM
1RCB
2B8U
2B8X
2B8Y
2B8Z
2B90
2B91
2CYK
2D48
2INT
3BPL
3BPN
3QB7
4YDY
5FHX
6OEL
Enriched GO Terms of Interacting Partners
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