PRMT1 and PDPN

Data Source:
BioGRID (affinity chromatography technology)

		PRMT1	PDPN
Description		protein arginine methyltransferase 1	podoplanin
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Methylosome	Ruffle Mitochondrion Cytosol Plasma Membrane Integral Component Of Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lamellipodium Cell Junction Filopodium Lamellipodium Membrane Cytoplasmic Vesicle Filopodium Membrane Microvillus Membrane Ruffle Membrane Cell Projection Membrane Raft Leading Edge Of Lamellipodium Tetraspanin-enriched Microdomain
	Molecular Function	RNA Binding Protein Binding Methyltransferase Activity N-methyltransferase Activity Protein Methyltransferase Activity Methyl-CpG Binding Protein-arginine N-methyltransferase Activity Enzyme Binding Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity Identical Protein Binding Histone Methyltransferase Activity (H4-R3 Specific) Mitogen-activated Protein Kinase P38 Binding S-adenosyl-L-methionine Binding	Signaling Receptor Binding Water Transmembrane Transporter Activity Protein Binding Folic Acid Transmembrane Transporter Activity Amino Acid Transmembrane Transporter Activity Water Channel Activity Chemokine Binding Chaperone Binding
	Biological Process	In Utero Embryonic Development Protein Methylation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Histone Methylation Peptidyl-arginine Methylation Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Neuron Projection Development Histone H4-R3 Methylation Positive Regulation Of Erythrocyte Differentiation Regulation Of Megakaryocyte Differentiation Negative Regulation Of Megakaryocyte Differentiation Positive Regulation Of Hemoglobin Biosynthetic Process Protein Homooligomerization Positive Regulation Of P38MAPK Cascade	Cell Morphogenesis Lymphangiogenesis Amino Acid Transmembrane Transport Water Transport Amino Acid Transport Rho Protein Signal Transduction Negative Regulation Of Cell Population Proliferation Regulation Of Cell Shape Positive Regulation Of Epithelial To Mesenchymal Transition Folic Acid Transport Platelet Activation Lung Development Positive Regulation Of Cell Migration Tube Morphogenesis Negative Regulation Of Apoptotic Process Wound Healing, Spreading Of Cells Lymph Node Development Positive Regulation Of Cellular Component Movement Response To Hyperoxia Lymphatic Endothelial Cell Fate Commitment Actin-mediated Cell Contraction Positive Regulation Of Extracellular Matrix Disassembly Cell-cell Adhesion Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Platelet Aggregation Regulation Of Myofibroblast Contraction Regulation Of Lamellipodium Morphogenesis
Pathways		RMTs methylate histone arginines TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Extra-nuclear estrogen signaling Estrogen-dependent gene expression	GPVI-mediated activation cascade
Drugs		S-adenosyl-L-homocysteine
Diseases
GWAS		Schizophrenia ( 29483656)
Interacting Genes		151 interacting genes: AR ARPC3 ASH2L AXIN1 BRCA1 BTG1 BTG2 C4orf17 CAPRIN1 CDC37 CEP162 CIRBP CNOT8 COIL DAXX DCAF16 DCAF8 DHX9 EIF4A1 EP300 ESR1 EWSR1 FAM83D FAM9A FBL FBXL17 FBXO7 FGF2 FLII FUS GLI1 GPATCH2L GRHL3 GRIP1 H3C1 H4-16 H4C14 HABP4 HNF4A HNRNPA1 HNRNPK HNRNPR HNRNPU HNRNPUL1 HROB IDH3B IFNAR1 IGSF21 ILF3 KHDRBS1 KHDRBS2 KHDRBS3 LRIF1 MBP MECOM MED31 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR138-1 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR206 MIR20A MIR20B MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR34A MIR34C MIR363 MIR451A MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MLST8 NCOA1 NCOA2 NCOA3 NOL4 NRIP1 NTAQ1 OFCC1 PPARA PRMT8 QKI RBM15 RELA RNF187 RUNX1 S100A8 SAMD3 SHLD1 SIRT1 SPAG8 SPEG SPSB1 SPSB2 STAT1 STAT5A STUB1 SUPT5H TBX6 TERF2 THRB TP53 TRIM48 UBE4B VHL VPS72 WDFY3 WDR33 YLPM1 YWHAG ZBTB14 ZMYM5 ZNF451	2 interacting genes: TMEM14B TOM1L1
Entrez ID		3276	10630
HPRD ID		04257	16398
Ensembl ID		ENSG00000126457	ENSG00000162493
Uniprot IDs		Q99873	Q86YL7
PDB IDs		6NT2	3WSR 4YO0 5XCV 7C94
Enriched GO Terms of Interacting Partners?
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