HPN and MEGF8

Data Source:
BioGRID (proximity labelling technology)

		HPN	MEGF8
Description		hepsin	multiple EGF like domains 8
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Cell Surface Integral Component Of Membrane Apical Plasma Membrane Nuclear Membrane Neuronal Cell Body Extracellular Exosome	Nucleus Integral Component Of Membrane Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Serine-type Exopeptidase Activity	Calcium Ion Binding Protein Binding
	Biological Process	Proteolysis Regulation Of Cell Shape Positive Regulation Of Gene Expression Negative Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Plasminogen Activation Positive Regulation Of Cell Growth Basement Membrane Disassembly Negative Regulation Of Apoptotic Process Positive Regulation By Host Of Viral Transcription Hepatocyte Growth Factor Receptor Signaling Pathway Negative Regulation Of Epithelial Cell Proliferation Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Potassium Ion Transmembrane Transport Cochlea Morphogenesis Response To Thyroid Hormone Pilomotor Reflex Positive Regulation Of Hepatocyte Proliferation Positive Regulation Of Thyroid Hormone Generation	Embryonic Heart Tube Morphogenesis Animal Organ Morphogenesis Tissue Development Regulation Of Gene Expression Embryonic Limb Morphogenesis BMP Signaling Pathway Limb Morphogenesis Cell Migration Involved In Gastrulation Negative Regulation Of Smoothened Signaling Pathway Embryonic Skeletal System Morphogenesis Positive Regulation Of Axon Extension Involved In Axon Guidance Epiboly Involved In Gastrulation With Mouth Forming Second Embryonic Heart Tube Left/right Pattern Formation Left/right Pattern Formation Coronary Vasculature Development Determination Of Heart Left/right Asymmetry Determination Of Digestive Tract Left/right Asymmetry Craniofacial Suture Morphogenesis Fasciculation Of Sensory Neuron Axon
Pathways		MET Receptor Activation Signaling by MST1
Drugs		Bentiromide Benzylsulfonic acid CRA_1144 6-Chloro-2-(2-Hydroxy-Biphenyl-3-Yl)-1h-Indole-5-Carboxamidine
Diseases
GWAS		C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Platelet count ( 32888494) Plateletcrit ( 32888494) Serum albumin level ( 23022100) Serum total protein level ( 29403010) Triglyceride levels ( 32203549 32154731) Urinary albumin-to-creatinine ratio ( 31511532) Urinary albumin-to-creatinine ratio in diabetes ( 31511532)
Interacting Genes		7 interacting genes: BNIP3 EGFR F7 GLP1R HGF SFTPC UPK2	3 interacting genes: ATN1 CACNA1A GFI1B
Entrez ID		3249	1954
HPRD ID		00801	10370
Ensembl ID		ENSG00000105707	ENSG00000105429
Uniprot IDs		A0A140VJK9 B7Z1L4 P05981	Q7Z7M0
PDB IDs		1O5E 1O5F 1P57 1Z8G 3T2N 5CE1
Enriched GO Terms of Interacting Partners?
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