APBA2 and LRP8

Data Source:
BioGRID (two hybrid)

		APBA2	LRP8
Description		amyloid beta precursor protein binding family A member 2	LDL receptor related protein 8
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Synaptic Vesicle Dendritic Spine	Extracellular Space Microtubule Associated Complex Plasma Membrane Caveola Cell Surface Postsynaptic Density Membrane Integral Component Of Membrane Axon Dendrite Neuronal Cell Body Receptor Complex
	Molecular Function	Amyloid-beta Binding Protein Binding Identical Protein Binding	Amyloid-beta Binding Transmembrane Signaling Receptor Activity Low-density Lipoprotein Particle Receptor Activity Calcium Ion Binding Protein Binding High-density Lipoprotein Particle Binding Kinesin Binding Very-low-density Lipoprotein Particle Receptor Activity Apolipoprotein Binding Cargo Receptor Activity Reelin Receptor Activity Protein N-terminus Binding Calcium-dependent Protein Binding
	Biological Process	Chemical Synaptic Transmission Nervous System Development Protein Transport	Retinoid Metabolic Process Proteolysis Lipid Metabolic Process Endocytosis Signal Transduction Chemical Synaptic Transmission Cytokine-mediated Signaling Pathway Ventral Spinal Cord Development Ammon Gyrus Development Layer Formation In Cerebral Cortex Positive Regulation Of CREB Transcription Factor Activity Reelin-mediated Signaling Pathway Response To Drug Regulation Of Apoptotic Process Regulation Of Innate Immune Response Dendrite Morphogenesis Positive Regulation Of Peptidyl-tyrosine Phosphorylation Modulation Of Chemical Synaptic Transmission Positive Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Protein Tyrosine Kinase Activity Cellular Response To Growth Factor Stimulus Cellular Response To Cholesterol Positive Regulation Of Dendrite Development
Pathways		Neurexins and neuroligins	Platelet sensitization by LDL Retinoid metabolism and transport
Drugs
Diseases
GWAS		Response to mTOR inhibitor (rapamycin) ( 24009623) Skin pigmentation (conditioned on rs1426654 and rs35397) ( 31315583) Temperament ( 22832960)	Blood protein levels ( 30072576) Body mass index (alcohol intake interaction) ( 23192594) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cerebrospinal fluid AB1-42 levels ( 28247064) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) General risk tolerance (MTAG) ( 30643258) Number of sexual partners ( 30643258) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Type 2 diabetes nephropathy ( 30566433) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		15 interacting genes: APP ARF3 ARF4 CLSTN1 CLSTN3 LRP1 LRP2 LRP8 MAGEB6 MAPK6 NECAB3 NRXN1 RELA STXBP1 USP20	21 interacting genes: ANAPC10 APBA2 APOE APOH CLU DAB1 DAB2 DLG4 GIPC1 GRIN1 ITGB1BP1 LRPAP1 MAPK8IP1 MAPK8IP2 MDK MYLIP NOS1AP RELN SCN3A SNX17 SYNJ2BP
Entrez ID		321	7804
HPRD ID		04090	04002
Ensembl ID		ENSG00000034053	ENSG00000157193
Uniprot IDs		Q59G28 Q99767	A0A590UJ98 Q14114
PDB IDs			3A7Q 5B4X 5B4Y
Enriched GO Terms of Interacting Partners?
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