APAF1 and CCL13

Data Source:
BioGRID (proximity labelling technology)

		APAF1	CCL13
Description		apoptotic peptidase activating factor 1	C-C motif chemokine ligand 13
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytosol Protein-containing Complex Secretory Granule Lumen Apoptosome Extracellular Exosome Ficolin-1-rich Granule Lumen	Extracellular Region Extracellular Space
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Heat Shock Protein Binding Identical Protein Binding ADP Binding	Signaling Receptor Binding Protein Binding Chemokine Activity CCR Chemokine Receptor Binding
	Biological Process	Response To Hypoxia Kidney Development Neural Tube Closure Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Nervous System Development Aging Response To Nutrient Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Cardiac Muscle Cell Apoptotic Process Cell Differentiation Forebrain Development Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Neutrophil Degranulation Neuron Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Negative Regulation Of G0 To G1 Transition Cellular Response To Transforming Growth Factor Beta Stimulus Response To G1 DNA Damage Checkpoint Signaling Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic DNA Fragmentation Positive Regulation Of Apoptotic Signaling Pathway	Monocyte Chemotaxis Cellular Calcium Ion Homeostasis Chemotaxis Inflammatory Response Cytoskeleton Organization Signal Transduction G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Regulation Of Cell Shape Neutrophil Chemotaxis Killing Of Cells Of Other Organism Positive Regulation Of GTPase Activity Eosinophil Chemotaxis Lymphocyte Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor
Pathways		Formation of apoptosome Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes Neutrophil degranulation TP53 Regulates Transcription of Caspase Activators and Caspases Transcriptional Regulation by E2F6 Regulation of the apoptosome activity Regulation of the apoptosome activity	Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs		ATP
Diseases
GWAS			Blood protein levels ( 29875488) Crohn's disease ( 22412388) Inflammatory bowel disease ( 23128233) Metabolite levels ( 23823483)
Interacting Genes		18 interacting genes: APIP AVEN BCL2L1 BCL2L10 CASP3 CASP4 CASP8 CASP9 CYCS FAS FEM1B HIP1 HSP90AA1 HSPA1A NLRP1 PPP1CA TOP1 TRIAP1	26 interacting genes: ACKR2 ACKR4 APP CCL11 CCL2 CCL21 CCL24 CCL26 CCL28 CCL5 CCL8 CCR3 CCR5 CXCL10 CXCL11 CXCL12 CXCL14 CXCL17 CXCL9 HNRNPH3 MMP1 MMP3 NOD2 PF4 PPBP XCL1
Entrez ID		317	6357
HPRD ID		03755	03230
Ensembl ID		ENSG00000120868	ENSG00000181374
Uniprot IDs		O14727	Q99616
PDB IDs		1C15 1CWW 1CY5 1Z6T 2P1H 2YGS 3J2T 3JBT 3YGS 4RHW 5JUY 5WVC 5WVE	2RA4
Enriched GO Terms of Interacting Partners?
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