APAF1 and CDK17

Data Source:
HPRD (in vitro, in vivo)

		APAF1	CDK17
Description		apoptotic peptidase activating factor 1	cyclin dependent kinase 17
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytosol Protein-containing Complex Secretory Granule Lumen Apoptosome Extracellular Exosome Ficolin-1-rich Granule Lumen	Nucleus Cytoplasm
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Heat Shock Protein Binding Identical Protein Binding ADP Binding	Protein Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding
	Biological Process	Response To Hypoxia Kidney Development Neural Tube Closure Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Nervous System Development Aging Response To Nutrient Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Cardiac Muscle Cell Apoptotic Process Cell Differentiation Forebrain Development Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Neutrophil Degranulation Neuron Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Negative Regulation Of G0 To G1 Transition Cellular Response To Transforming Growth Factor Beta Stimulus Response To G1 DNA Damage Checkpoint Signaling Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic DNA Fragmentation Positive Regulation Of Apoptotic Signaling Pathway	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Protein Phosphorylation Regulation Of Cell Cycle
Pathways		Formation of apoptosome Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes Neutrophil degranulation TP53 Regulates Transcription of Caspase Activators and Caspases Transcriptional Regulation by E2F6 Regulation of the apoptosome activity Regulation of the apoptosome activity
Drugs		ATP	Fostamatinib
Diseases
GWAS			Diastolic blood pressure ( 30224653) Manganese levels ( 26025379) Phospholipid levels (plasma) ( 22359512)
Interacting Genes		18 interacting genes: APIP AVEN BCL2L1 BCL2L10 CASP3 CASP4 CASP8 CASP9 CYCS FAS FEM1B HIP1 HSP90AA1 HSPA1A NLRP1 PPP1CA TOP1 TRIAP1	12 interacting genes: APP BICDL2 CDKN2B DPY30 EPHA2 PRKACG TDRD7 TGFBR1 UBC YWHAG YWHAQ YWHAZ
Entrez ID		317	5128
HPRD ID		03755	09141
Ensembl ID		ENSG00000120868	ENSG00000059758
Uniprot IDs		O14727	A0A024RBH0 Q00537
PDB IDs		1C15 1CWW 1CY5 1Z6T 2P1H 2YGS 3J2T 3JBT 3YGS 4RHW 5JUY 5WVC 5WVE
Enriched GO Terms of Interacting Partners?
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