HLCS and SOD1

Data Source:
HPRD (in vivo)

		HLCS	SOD1
Description		holocarboxylase synthetase	superoxide dismutase 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nuclear Lamina Cytoplasm Mitochondrion Cytosol Nuclear Matrix	Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Intermembrane Space Mitochondrial Matrix Lysosome Peroxisome Cytosol Plasma Membrane Dense Core Granule Cytoplasmic Vesicle Dendrite Cytoplasm Protein-containing Complex Neuronal Cell Body Extracellular Exosome Axon Cytoplasm
	Molecular Function	Biotin-[acetyl-CoA-carboxylase] Ligase Activity Biotin-[methylcrotonoyl-CoA-carboxylase] Ligase Activity Biotin-[methylmalonyl-CoA-carboxytransferase] Ligase Activity Biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] Ligase Activity Protein Binding ATP Binding Biotin Binding Biotin-protein Ligase Activity Enzyme Binding	Superoxide Dismutase Activity Copper Ion Binding Protein Binding Zinc Ion Binding Protein Phosphatase 2B Binding Small GTPase Binding Identical Protein Binding Chaperone Binding
	Biological Process	Biotin Metabolic Process Protein Biotinylation Histone Modification Protein Phosphopantetheinylation Response To Biotin Histone Biotinylation	Activation Of MAPK Activity Response To Superoxide Ovarian Follicle Development Positive Regulation Of Cytokine Production Placenta Development Retina Homeostasis Response To Amphetamine Myeloid Cell Homeostasis Platelet Degranulation Glutathione Metabolic Process Superoxide Metabolic Process Cellular Iron Ion Homeostasis Spermatogenesis Embryo Implantation Cell Aging Sensory Perception Of Sound Locomotory Behavior Anterograde Axonal Transport Retrograde Axonal Transport Regulation Of Blood Pressure Response To Heat Response To Organic Substance Transmission Of Nerve Impulse Removal Of Superoxide Radicals Response To Nutrient Levels Peripheral Nervous System Myelin Maintenance Positive Regulation Of Superoxide Anion Generation Regulation Of T Cell Differentiation In Thymus Response To Carbon Monoxide Cellular Response To Oxidative Stress Interleukin-12-mediated Signaling Pathway Cellular Response To Potassium Ion Regulation Of Multicellular Organism Growth Response To Drug Response To Hydrogen Peroxide Superoxide Anion Generation Positive Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Regulation Of GTPase Activity Negative Regulation Of Neuron Apoptotic Process Response To Ethanol Negative Regulation Of Cholesterol Biosynthetic Process Regulation Of Protein Kinase Activity Regulation Of Organ Growth Response To Antibiotic Response To Copper Ion Muscle Cell Cellular Homeostasis Thymus Development Response To Axon Injury Hydrogen Peroxide Biosynthetic Process Negative Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Regulation Of Mitochondrial Membrane Potential Heart Contraction Neurofilament Cytoskeleton Organization Relaxation Of Vascular Associated Smooth Muscle Auditory Receptor Cell Stereocilium Organization Cellular Response To Cadmium Ion Cellular Response To ATP Reactive Oxygen Species Metabolic Process Response To Antipsychotic Drug Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Pathways		Biotin transport and metabolism Defective HLCS causes multiple carboxylase deficiency	Platelet degranulation Detoxification of Reactive Oxygen Species Detoxification of Reactive Oxygen Species Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs		Biotin	Dopamine Isoprenaline Zinc 5-fluorouridine S-oxy-L-cysteine Arimoclomol Cannabidiol Medical Cannabis Nabiximols Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		Holocarboxylase synthetase deficiency	Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
GWAS		Developmental language disorder ( 27016271) Developmental language disorder (linguistic errors) ( 27016271) Hematocrit ( 32888494) Hemoglobin ( 32888494) Intracranial aneurysm ( 29531279) Night sleep phenotypes ( 27126917) Red blood cell count ( 32888494) Seasonality and depression ( 30217971)	Amyotrophic lateral sclerosis ( 20801718)
Interacting Genes		8 interacting genes: ACACB ANKRD29 DDX52 KRTAP5-9 MED19 POT1 SNX27 SPATA46	14 interacting genes: AMFR BCL2 CCS COMMD1 CRYAB DNAJB1 HOXB2 KARS1 MARCHF5 PARK7 PPP3CA RNF19A SMAD2 UBE3A
Entrez ID		3141	6647
HPRD ID		08360	00937
Ensembl ID		ENSG00000159267	ENSG00000142168
Uniprot IDs		P50747	P00441 V9HWC9
PDB IDs			1AZV 1BA9 1DSW 1FUN 1HL4 1HL5 1KMG 1L3N 1MFM 1N18 1N19 1OEZ 1OZT 1OZU 1P1V 1PTZ 1PU0 1RK7 1SOS 1SPD 1UXL 1UXM 2AF2 2C9S 2C9U 2C9V 2GBT 2GBU 2GBV 2LU5 2MP3 2NAM 2NNX 2R27 2V0A 2VR6 2VR7 2VR8 2WKO 2WYT 2WYZ 2WZ0 2WZ5 2WZ6 2XJK 2XJL 2ZKW 2ZKX 2ZKY 3CQP 3CQQ 3ECU 3ECV 3ECW 3GQF 3GTV 3GZO 3GZP 3GZQ 3H2P 3H2Q 3HFF 3K91 3KH3 3KH4 3LTV 3QQD 3RE0 3T5W 4A7G 4A7Q 4A7S 4A7T 4A7U 4A7V 4B3E 4BCY 4BCZ 4BD4 4FF9 4MCM 4MCN 4NIN 4NIO 4NIP 4OH2 4SOD 4XCR 5DLI 5IIW 5J07 5J0C 5J0F 5J0G 5K02 5O3Y 5O40 5U9M 5WMJ 5WOR 5YTO 5YTU 5YUL 6A9O 6B79 6DTK 6FFK 6FLH 6FOI 6FOL 6FON 6FP6 6SPA 6SPH 6SPI 6SPJ 6SPK 6Z3V 6Z4G 6Z4H 6Z4I 6Z4J 6Z4K 6Z4L 6Z4M 6Z4O
Enriched GO Terms of Interacting Partners?
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