HLCS and LANCL2

Data Source:
BioGRID (affinity chromatography technology)

		HLCS	LANCL2
Description		holocarboxylase synthetase	LanC like 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nuclear Lamina Cytoplasm Mitochondrion Cytosol Nuclear Matrix	Nucleus Nucleoplasm Cytosol Plasma Membrane Cortical Actin Cytoskeleton
	Molecular Function	Biotin-[acetyl-CoA-carboxylase] Ligase Activity Biotin-[methylcrotonoyl-CoA-carboxylase] Ligase Activity Biotin-[methylmalonyl-CoA-carboxytransferase] Ligase Activity Biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] Ligase Activity Protein Binding ATP Binding Biotin Binding Biotin-protein Ligase Activity Enzyme Binding	Protein Binding ATP Binding GTP Binding Phosphatidylinositol-5-phosphate Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-4-phosphate Binding
	Biological Process	Biotin Metabolic Process Protein Biotinylation Histone Modification Protein Phosphopantetheinylation Response To Biotin Histone Biotinylation	Carbohydrate Metabolic Process Positive Regulation Of Abscisic Acid-activated Signaling Pathway Negative Regulation Of Transcription, DNA-templated
Pathways		Biotin transport and metabolism Defective HLCS causes multiple carboxylase deficiency
Drugs		Biotin
Diseases		Holocarboxylase synthetase deficiency
GWAS		Developmental language disorder ( 27016271) Developmental language disorder (linguistic errors) ( 27016271) Hematocrit ( 32888494) Hemoglobin ( 32888494) Intracranial aneurysm ( 29531279) Night sleep phenotypes ( 27126917) Red blood cell count ( 32888494) Seasonality and depression ( 30217971)	Impulsivity ( 30718321) Mercury levels ( 26025379) Metabolite levels ( 23823483) QRS interval (sulfonylurea treatment interaction) ( 27958378) Spatial processing ( 31596458)
Interacting Genes		8 interacting genes: ACACB ANKRD29 DDX52 KRTAP5-9 MED19 POT1 SNX27 SPATA46	8 interacting genes: AKT1 APP APPBP2 RHOU SIAH1 TDRKH TERF2 TERF2IP
Entrez ID		3141	55915
HPRD ID		08360	13956
Ensembl ID		ENSG00000159267	ENSG00000132434
Uniprot IDs		P50747	B3KTN5 Q9NS86
PDB IDs
Enriched GO Terms of Interacting Partners?
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