HLCS and IFNAR2

Data Source:
BioGRID (affinity chromatography technology)

		HLCS	IFNAR2
Description		holocarboxylase synthetase	interferon alpha and beta receptor subunit 2
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nuclear Lamina Cytoplasm Mitochondrion Cytosol Nuclear Matrix	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Biotin-[acetyl-CoA-carboxylase] Ligase Activity Biotin-[methylcrotonoyl-CoA-carboxylase] Ligase Activity Biotin-[methylmalonyl-CoA-carboxytransferase] Ligase Activity Biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] Ligase Activity Protein Binding ATP Binding Biotin Binding Biotin-protein Ligase Activity Enzyme Binding	Cytokine Receptor Activity Type I Interferon Receptor Activity Protein Binding Protein Kinase Binding
	Biological Process	Biotin Metabolic Process Protein Biotinylation Histone Modification Protein Phosphopantetheinylation Response To Biotin Histone Biotinylation	Cell Surface Receptor Signaling Pathway Receptor Signaling Pathway Via JAK-STAT Response To Virus Cytokine-mediated Signaling Pathway Response To Interferon-alpha Response To Interferon-beta Defense Response To Virus Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway
Pathways		Biotin transport and metabolism Defective HLCS causes multiple carboxylase deficiency
Drugs		Biotin	Peginterferon alfa-2a Interferon alfa-n1 Interferon alfa-n3 Peginterferon alfa-2b Interferon alfa-2a, Recombinant Interferon beta-1a Interferon beta-1b Interferon alfacon-1 Interferon alfa-2b Human interferon omega-1 Nylidrin
Diseases		Holocarboxylase synthetase deficiency
GWAS		Developmental language disorder ( 27016271) Developmental language disorder (linguistic errors) ( 27016271) Hematocrit ( 32888494) Hemoglobin ( 32888494) Intracranial aneurysm ( 29531279) Night sleep phenotypes ( 27126917) Red blood cell count ( 32888494) Seasonality and depression ( 30217971)	Attention deficit hyperactivity disorder ( 30563984) Cerebellum white matter volume ( 31530798) Crohn's disease ( 23128233) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Type 2 diabetes ( 30130595)
Interacting Genes		8 interacting genes: ACACB ANKRD29 DDX52 KRTAP5-9 MED19 POT1 SNX27 SPATA46	14 interacting genes: IFNA2 IFNA5 IFNA8 IFNAR1 IFNB1 JAK1 PPP1R3B PRKCB RACK1 STAT1 STAT2 STAT3 TYK2 USP18
Entrez ID		3141	3455
HPRD ID		08360	03850
Ensembl ID		ENSG00000159267	ENSG00000159110
Uniprot IDs		P50747	P48551 Q9BUA0
PDB IDs			1N6U 1N6V 2HYM 2KZ1 2LAG 3S8W 3S9D 3SE3 3SE4
Enriched GO Terms of Interacting Partners?
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