HLA-G and COPB1

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		HLA-G	COPB1
Description		major histocompatibility complex, class I, G	COPI coat complex subunit beta 1
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Space Early Endosome Plasma Membrane External Side Of Plasma Membrane ER To Golgi Transport Vesicle Membrane Membrane Phagocytic Vesicle Membrane Filopodium Membrane Early Endosome Membrane Cis-Golgi Network Membrane MHC Class I Protein Complex Recycling Endosome Membrane Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane	Golgi Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Golgi-associated Vesicle Cytosol Plasma Membrane Membrane COPI Vesicle Coat Transport Vesicle Secretory Granule Membrane Intracellular Membrane-bounded Organelle Tertiary Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding Peptide Antigen Binding CD8 Receptor Binding Identical Protein Binding Protein Homodimerization Activity	Structural Molecule Activity Protein Binding
	Biological Process	Negative Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of T Cell Mediated Cytotoxicity Peripheral B Cell Tolerance Induction Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Positive Regulation Of Tolerance Induction Positive Regulation Of T Cell Tolerance Induction Positive Regulation Of Natural Killer Cell Cytokine Production Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Immune Response Cellular Defense Response Negative Regulation Of Angiogenesis Positive Regulation Of Interleukin-12 Production Negative Regulation Of T Cell Proliferation Protection From Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response Negative Regulation Of Immune Response Negative Regulation Of Protein Kinase B Signaling Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Positive Regulation Of Macrophage Cytokine Production Protein Homotrimerization Negative Regulation Of G0 To G1 Transition Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Cellular Senescence Negative Regulation Of Dendritic Cell Differentiation	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Intra-Golgi Vesicle-mediated Transport Viral Process Neutrophil Degranulation
Pathways		ER-Phagosome pathway ER-Phagosome pathway Endosomal/Vacuolar pathway Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Interferon gamma signaling Interferon alpha/beta signaling Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC	Neutrophil degranulation COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Childhood ear infection ( 27182965) Colorectal cancer ( 30529582) Crohn's disease ( 22412388) Eosinophil percentage of white cells ( 32888494) HDL cholesterol levels ( 32203549) IgE levels ( 22075330) IgM levels ( 28628107) LDL cholesterol levels ( 32203549) Lung adenocarcinoma ( 28604730) Neutrophil percentage of white cells ( 32888494) Non-albumin protein levels ( 29403010) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Smoking status (ever vs never smokers) ( 30643258) Takayasu arteritis ( 25604533) Triglyceride levels ( 32203549)	HDL cholesterol ( 26780889) HDL cholesterol levels ( 32203549 28334899) Height ( 31562340) High chromosomal aberration frequency (total) ( 31586183) Vitamin D levels ( 25208829)
Interacting Genes		10 interacting genes: B2M CD8A CDC42 COPB1 KIR2DL4 KLRD1 LILRB1 LILRB2 TAP1 TAP2	44 interacting genes: ADAM19 APP ARCN1 ARF1 BCAR1 COPE COPG1 COPG2 ERBIN FOXB1 GORAB GRB2 GTPBP4 HLA-DPB1 HLA-G ID1 IRAK3 KCNK3 KDELR1 KIAA1328 LINC00839 LZTS1 LZTS2 NUB1 PDGFRB PRKCE PTEN RGS2 RGS4 RHOQ SCYL1 SERTAD1 SNTA1 SPTBN1 TANK TAPBP TMED10 TRIM37 TTYH2 UBC UBQLN4 VPS18 WBP2 XRCC6
Entrez ID		3135	1315
HPRD ID		00834	02981
Ensembl ID		ENSG00000204632	ENSG00000129083
Uniprot IDs		P17693 Q31611 Q6DU14	P53618
PDB IDs		1YDP 2D31 2DYP 3BZE 3CDG 3CII 3KYN 3KYO 6AEE 6K60
Enriched GO Terms of Interacting Partners?
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