HLA-DQA2 and HLA-DQB1

Data Source:
HPRD (in vitro, in vivo)

		HLA-DQA2	HLA-DQB1
Description		major histocompatibility complex, class II, DQ alpha 2	major histocompatibility complex, class II, DQ beta 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane Endosome Membrane ER To Golgi Transport Vesicle Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane	Golgi Membrane Lysosomal Membrane Plasma Membrane Endosome Membrane ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Protein Binding MHC Class II Receptor Activity	Protein Binding MHC Class II Receptor Activity Peptide Antigen Binding
	Biological Process	Adaptive Immune Response Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II T Cell Receptor Signaling Pathway Interferon-gamma-mediated Signaling Pathway	Immunoglobulin Production Involved In Immunoglobulin-mediated Immune Response Humoral Immune Response Mediated By Circulating Immunoglobulin Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II T Cell Receptor Signaling Pathway Interferon-gamma-mediated Signaling Pathway
Pathways		Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation PD-1 signaling Interferon gamma signaling	Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation PD-1 signaling Interferon gamma signaling
Drugs		Insulin pork	Insulin pork
Diseases			Type I diabetes mellitus Viral myocarditis Dilated cardiomyopathy (DCM) Tuberculosis Asthma Graves' disease Systemic lupus erythematosus Hashimoto's thyroiditis
GWAS		Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001) Alopecia areata ( 20596022) Asthma ( 21804548 31959851 31619474) Asthma and major depressive disorder ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Autism spectrum disorder or schizophrenia ( 28540026) Basal cell carcinoma ( 27539887) Blood protein levels ( 29875488) Body mass index ( 25673413) Chronic hepatitis B infection ( 24940741) Coffee consumption (cups per day) ( 31837886) Crohn's disease ( 21102463 26891255 23266558) Giant cell arteritis ( 28041642) Glycated hemoglobin levels ( 31213470) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Height ( 31562340) Hepatitis C (spontaneous viral clearance) ( 30593799) Hypothyroidism ( 22493691) IgA levels ( 28628107) IgE levels ( 23146381 22075330) IgG glycosylation ( 23382691) Inflammatory bowel disease ( 28067908) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Knee osteoarthritis ( 20305777) Lung cancer in ever smokers ( 28604730) Lung function (FEV1) ( 28166213) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Lymphoma ( 23349640) Mild influenza (H1N1) infection ( 26379185) Mosquito bite size ( 28199695) Multiple sclerosis (OCB status) ( 23472185) Myositis ( 26291516) Narcolepsy ( 20711174) Peanut allergy ( 25710614) Pulmonary function (smoking interaction) ( 23284291) Red blood cell count ( 29403010) Response to hepatitis B vaccine ( 29534301) Rheumatoid arthritis ( 18668548 24782177 23918589) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Severe aplastic anemia ( 32004448) SjÃ¶gren's syndrome ( 28076899) Systemic lupus erythematosus ( 24871463 23053960 21408207) Thyrotoxic hypokalemic periodic paralysis and Graves disease ( 31050781) Type 2 diabetes ( 22693455) Ulcerative colitis ( 28067908) Vasculitis associated with antineutrophil cytoplasmic antibody reactive to myeloperoxidase ( 28029757)	Acute-on-chronic liver failure in hepatitis B ( 28130311) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184 31361310) Allergic sensitization ( 23817571) Allergy ( 27182965) Alopecia areata ( 25608926) Anti-Epstein-Barr virus nuclear antigen (EBNA) IgG levels ( 30053915) Anti-varicella zoster virus IgG seropositivity ( 33204752) Asthma ( 21804548 31361310 31959851 30929738 31619474) Asthma (moderate or severe) ( 30552067) Asthma and hay fever ( 24388013) Asthma and major depressive disorder ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Autism spectrum disorder or schizophrenia ( 28540026) Autoimmune hepatitis in primary sclerosing cholangitis ( 28779025) Automobile speeding propensity ( 30643258) Blood protein levels ( 29875488) Body size at age 10 ( 32376654) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Cataracts (operation) ( 31816047) CCL19 levels ( 25147954) Celiac disease ( 20190752) Cervical cancer ( 28806749) Childhood ear infection ( 28928442) Childhood steroid-sensitive nephrotic syndrome ( 31263063 29903748) Chronic hepatitis B infection ( 25802187) Chronic hepatitis C infection ( 24376798) Chronic lymphocytic leukemia ( 26956414) Chronic obstructive pulmonary disease ( 30804561) Crohn's disease ( 30500874 26891255 23266558) Diastolic blood pressure ( 27618447) Drug-induced liver injury (flucloxacillin) ( 30661239) Eczema ( 31361310) Emphysema imaging phenotypes ( 26030696) Enteric fever ( 25383971) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494) Epstein-Barr virus immune response (EBNA-1) ( 23326239) FEV1 ( 30804560) Follicular lymphoma ( 20639881 21533074) Glucosuria ( 30476138) Glucosuria (moderate to severe) ( 30476138) HDL cholesterol levels ( 32203549) Head and neck squamous cell carcinoma ( 32276964) Height ( 31562340) Helicobacter pylori OMP antibody levels ( 33204752) Hepatitis B ( 21750111 28928442) Hepatitis C (spontaneous viral clearance) ( 30593799) Hepatocellular carcinoma in hepatitis C infection ( 28921602) High altitude adaptation ( 28373541) HPV seropositivity ( 21896673) Hypothyroidism ( 27182965 22493691) IgA nephropathy ( 26028593 25305756) IgE levels ( 23146381) IgG levels ( 28628107) Immunoglobulin A vasculitis ( 28698626) Inflammatory bowel disease ( 28067908) Iron status biomarkers (iron levels) ( 28334935) Iron status biomarkers (transferrin saturation) ( 28334935) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Kawasaki disease ( 33106546) Knee osteoarthritis ( 20305777) Late-onset myasthenia gravis ( 26562150) Latent autoimmune diabetes vs. type 1 diabetes ( 30254083) Latent autoimmune diabetes vs. type 2 diabetes ( 30254083) LDL cholesterol levels ( 32203549) Lung cancer in ever smokers ( 28604730) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 28166213 30804560) Lung function (low FEV1 vs high FEV1) ( 26423011) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Lymphocyte percentage of white cells ( 27863252) Lymphoma ( 23349640) Mean corpuscular volume ( 32888494) Medication use (antihistamines for systemic use) ( 31015401) Medication use (drugs used in diabetes) ( 31015401) Medication use (thyroid preparations) ( 31015401) Moderate to vigorous physical activity levels ( 29899525) Mosquito bite size ( 28199695) Multiple sclerosis ( 20453840) Multiple sclerosis (OCB status) ( 23472185) Myositis ( 26291516) Nephropathy ( 21399633) Neuromyelitis optica ( 29769526) Neuromyelitis optica (AQP4-IgG-positive) ( 29769526) Neutrophil count ( 32888494) Nodular sclerosis Hodgkin lymphoma ( 22086417) Oral cavity and pharyngeal cancer ( 27749845) Oral cavity cancer ( 32276964) Oropharynx cancer ( 27749845) Parkinson's disease ( 31660654) Peak expiratory flow ( 30804560) Peanut allergy ( 25710614) PEG-asparaginase hypersensitivity without enzyme activity in childhood acute lymphoblastic leukaemia ( 30450575) Plantar warts ( 28928442) Pneumonia ( 28928442) Primary biliary cholangitis ( 19458352 20639880) Primary biliary cirrhosis ( 22961000) Prostate cancer ( 23535732) Pulmonary function ( 21946350) Pulmonary function (smoking interaction) ( 23284291) Red blood cell count ( 29403010) Response to hepatitis B vaccine ( 29534301) Rheumatic heart disease ( 32488134) Rheumatoid arthritis ( 24782177 23918589) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Scarlet fever ( 28928442) Schizophrenia ( 30285260) Self-reported allergy ( 23817569) Sero-negative rheumatoid arthritis ( 28706201) Serum IgE levels ( 25488688) Serum uric acid levels ( 30993211) Shingles ( 28928442) SjÃ¶gren's syndrome ( 24097067 28076899) Strep throat ( 28928442) Systemic lupus erythematosus ( 24871463 26606652 26316170 26502338) Systemic sclerosis ( 20383147 21779181) Takayasu arteritis ( 23830517) Thyrotoxic hypokalemic periodic paralysis and Graves disease ( 31050781) Tonsillectomy ( 28928442) Triglyceride levels ( 32203549) Tuberculosis ( 29036319 28928442) Type 1 diabetes ( 31152121) Type 2 diabetes ( 30054458) Ulcerative colitis ( 24837172 28067908 23128233 19122664) Urate levels ( 31985003) White blood cell count ( 32888494) Yeast infection ( 28928442)
Interacting Genes		4 interacting genes: CD4 HLA-DQB1 INS LHFPL5	5 interacting genes: CD4 CD74 HLA-DQA1 HLA-DQA2 INS
Entrez ID		3118	3119
HPRD ID		09982	05054
Ensembl ID		ENSG00000237541	ENSG00000179344
Uniprot IDs		P01906 Q76NI6	P01920 Q5SU54 Q5Y7A9 Q5Y7D3 Q5Y7D6
PDB IDs			1JK8 1NBN 1S9V 1UVQ 2NNA 4D8P 4GG6 4OZF 4OZG 4OZH 4OZI 5KSU 5KSV 6DIG
Enriched GO Terms of Interacting Partners?
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