HLA-DQA1 and HLA-DQB1

Data Source:
BioGRID (fluorescent resonance energy transfer, affinity chromatography technology)

		HLA-DQA1	HLA-DQB1
Description		major histocompatibility complex, class II, DQ alpha 1	major histocompatibility complex, class II, DQ beta 1
Image
GO Annotations	Cellular Component	Golgi Membrane Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane Endosome Membrane ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane	Golgi Membrane Lysosomal Membrane Plasma Membrane Endosome Membrane ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Protein Binding MHC Class II Receptor Activity Peptide Antigen Binding	Protein Binding MHC Class II Receptor Activity Peptide Antigen Binding
	Biological Process	Adaptive Immune Response Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II T Cell Receptor Signaling Pathway Interferon-gamma-mediated Signaling Pathway	Immunoglobulin Production Involved In Immunoglobulin-mediated Immune Response Humoral Immune Response Mediated By Circulating Immunoglobulin Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II T Cell Receptor Signaling Pathway Interferon-gamma-mediated Signaling Pathway
Pathways		Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation PD-1 signaling Interferon gamma signaling	Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation PD-1 signaling Interferon gamma signaling
Drugs			Insulin pork
Diseases		Type I diabetes mellitus Dilated cardiomyopathy (DCM) Graves' disease Systemic lupus erythematosus Hashimoto's thyroiditis	Type I diabetes mellitus Viral myocarditis Dilated cardiomyopathy (DCM) Tuberculosis Asthma Graves' disease Systemic lupus erythematosus Hashimoto's thyroiditis
GWAS		Adult asthma ( 30578877) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 30013184) Allergic sensitization ( 23817571) Allergy ( 27182965) Anti-Epstein-Barr virus nuclear antigen (EBNA) IgG levels ( 32737300) Anti-polyomavirus 2 IgG seropositivity ( 33204752) Antineutrophil cytoplasmic antibody-associated vasculitis ( 28029757) Apolipoprotein B levels ( 32203549) Asthma ( 31361310 31959851 30929738 27182965 32296059 31619474 29273806 23181788) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma (moderate or severe) ( 30552067) Asthma (time to onset) ( 27130862) Asthma and major depressive disorder ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 26482879) Autism spectrum disorder or schizophrenia ( 28540026) Autoimmune hepatitis in primary sclerosing cholangitis ( 28779025) Autoimmune hepatitis type-1 ( 24768677) Autoimmune thyroid disease ( 32581359) Basal cell carcinoma ( 31174203) Blood protein levels ( 29875488) Body mass index ( 28892062) C-reactive protein levels ( 30388399) Celiac disease ( 20190752 17558408) Cervical cancer ( 23482656 28806749) Childhood ear infection ( 27182965 28928442) Childhood steroid-sensitive nephrotic syndrome ( 31263063 29903748) Chronic hepatitis C infection ( 24376798) Chronic lymphocytic leukemia ( 21131588) Chronic rhinosinusitis ( 30643255) Composite immunoglobulin trait (IgA x IgG x IgM) ( 28628107) Creatinine levels ( 29403010) Crohn's disease ( 23850713 26891255 23266558) Cutaneous lupus erythematosus ( 25827949) Cutaneous squamous cell carcinoma ( 32041948) Drug-induced liver injury (flucloxacillin) ( 30661239) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophil counts ( 32888494) Epstein Barr virus nuclear antigen 1 IgG levels ( 26819262 29868224) Epstein Barr virus nuclear antigen 1 IgG seropositivity ( 29868224) Epstein-Barr virus EBNA-1 antibody levels ( 33204752) Epstein-Barr virus immune response (multivariate analysis) ( 29868224) Epstein-Barr virus VCA p18 antibody levels ( 33204752) Epstein-Barr virus ZEBRA antibody levels ( 33204752) Estimated glomerular filtration rate ( 30604766) Factor VIII levels ( 30586737) Giant cell arteritis ( 28041642 25817017) Glomerular filtration rate ( 29403010) Granulocyte percentage of myeloid white cells ( 27863252) Hand grip strength ( 29691431) Hematocrit ( 27863252) Hemoglobin levels ( 32327693) Hepatocellular carcinoma ( 22807686) Herpes simplex virus 6 IE1B antibody levels ( 33204752) Herpes simplex virus 7 U14 antibody levels ( 33204752) High density lipoprotein cholesterol levels ( 29403010) Hypothyroidism ( 27182965 22493691) Idiopathic membranous nephropathy ( 21323541) IgA nephropathy ( 26028593 25305756) Immune response to anthrax vaccine ( 22658931) Immunoglobulin A vasculitis ( 28698626) Immunoglobulin G index levels in multiple sclerosis ( 25616667) Inflammatory bowel disease ( 28008999 18758464 28067908) Intraocular pressure ( 29785010) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Keratinocyte cancer (MTAG) ( 31174203) Late-onset myasthenia gravis ( 26562150) Leishmaniasis (visceral) ( 23291585) Leprosy ( 32421744) Low density lipoprotein cholesterol levels ( 32154731) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Lymphocyte counts ( 29403010 32888494) Lymphocyte percentage of white cells ( 32888494) Lymphoma ( 23349640) Mean corpuscular hemoglobin ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Medication use (glucocorticoids) ( 31015401) Membranous nephropathy ( 27333618) Mixed cryoglobulinemia vasculitis in chronic hepatitis C infection ( 25030430) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Multiple sclerosis (OCB status) ( 23472185) Myasthenia gravis ( 25643325) Myositis ( 26291516) Nasal polyps ( 30643255) Nephropathy ( 21399633) Neuroblastoma or malignant cutaneous melanoma ( 31605138) Neuromyelitis optica ( 29769526) Neuromyelitis optica (AQP4-IgG-positive) ( 29769526) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Oligoclonal band status in multiple sclerosis ( 25616667) Oropharynx cancer ( 32276964) Parental lifespan ( 30642433 29030599) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Parental longevity (mother's attained age) ( 29227965) Parkinson's disease ( 27182965 28892059) Peanut allergy ( 25710614) PEG-asparaginase hypersensitivity without enzyme activity in childhood acute lymphoblastic leukaemia ( 30450575) Plantar warts ( 28928442) Pneumonia ( 28928442) Primary biliary cirrhosis ( 22961000) Primary sclerosing cholangitis ( 23603763) Prostate cancer ( 23535732) Red blood cell count ( 27863252) Refractive error ( 32231278) Response to hepatitis B vaccine ( 29534301) Response to interferon beta therapy ( 21502966) Rheumatoid arthritis ( 18668548 23918589) Rheumatoid arthritis (ACPA-negative) ( 24532677) Rosacea symptom severity ( 29771307) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Scarlet fever ( 28928442) Schizophrenia ( 23212062 19571809) Selective IgA deficiency ( 27723758) Self-reported allergy ( 23817569) Shingles ( 28928442) SjÃ¶gren's syndrome ( 24097066 24097067 28076899) Small cell lung carcinoma ( 28604730) Squamous cell carcinoma ( 31174203 26829030) Squamous cell lung carcinoma ( 28604730) Strep throat ( 28928442) Systemic lupus erythematosus ( 24871463 26606652 26316170 18204098 21408207) Systemic sclerosis ( 21779181) Takayasu arteritis ( 25604533) Thyroid stimulating hormone levels ( 32769997) Tonsillectomy ( 28928442) Total bilirubin levels ( 29403010) Triglyceride levels ( 32203549) Tuberculosis ( 28928442) Type 2 diabetes ( 28566273) Ulcerative colitis ( 28008999 24837172 28067908 26278503 23128233 21297633 19122664 23511034) Urate levels ( 31578528) Varicella zoster virus glycoproteins E and I antibody levels ( 33204752) Vitiligo ( 20410501 27723757) Vogt-Koyanagi-Harada syndrome ( 25108386) White blood cell count ( 32888494)	Acute-on-chronic liver failure in hepatitis B ( 28130311) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184 31361310) Allergic sensitization ( 23817571) Allergy ( 27182965) Alopecia areata ( 25608926) Anti-Epstein-Barr virus nuclear antigen (EBNA) IgG levels ( 30053915) Anti-varicella zoster virus IgG seropositivity ( 33204752) Asthma ( 21804548 31361310 31959851 30929738 31619474) Asthma (moderate or severe) ( 30552067) Asthma and hay fever ( 24388013) Asthma and major depressive disorder ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Autism spectrum disorder or schizophrenia ( 28540026) Autoimmune hepatitis in primary sclerosing cholangitis ( 28779025) Automobile speeding propensity ( 30643258) Blood protein levels ( 29875488) Body size at age 10 ( 32376654) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Cataracts (operation) ( 31816047) CCL19 levels ( 25147954) Celiac disease ( 20190752) Cervical cancer ( 28806749) Childhood ear infection ( 28928442) Childhood steroid-sensitive nephrotic syndrome ( 31263063 29903748) Chronic hepatitis B infection ( 25802187) Chronic hepatitis C infection ( 24376798) Chronic lymphocytic leukemia ( 26956414) Chronic obstructive pulmonary disease ( 30804561) Crohn's disease ( 30500874 26891255 23266558) Diastolic blood pressure ( 27618447) Drug-induced liver injury (flucloxacillin) ( 30661239) Eczema ( 31361310) Emphysema imaging phenotypes ( 26030696) Enteric fever ( 25383971) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494) Epstein-Barr virus immune response (EBNA-1) ( 23326239) FEV1 ( 30804560) Follicular lymphoma ( 20639881 21533074) Glucosuria ( 30476138) Glucosuria (moderate to severe) ( 30476138) HDL cholesterol levels ( 32203549) Head and neck squamous cell carcinoma ( 32276964) Height ( 31562340) Helicobacter pylori OMP antibody levels ( 33204752) Hepatitis B ( 21750111 28928442) Hepatitis C (spontaneous viral clearance) ( 30593799) Hepatocellular carcinoma in hepatitis C infection ( 28921602) High altitude adaptation ( 28373541) HPV seropositivity ( 21896673) Hypothyroidism ( 27182965 22493691) IgA nephropathy ( 26028593 25305756) IgE levels ( 23146381) IgG levels ( 28628107) Immunoglobulin A vasculitis ( 28698626) Inflammatory bowel disease ( 28067908) Iron status biomarkers (iron levels) ( 28334935) Iron status biomarkers (transferrin saturation) ( 28334935) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Kawasaki disease ( 33106546) Knee osteoarthritis ( 20305777) Late-onset myasthenia gravis ( 26562150) Latent autoimmune diabetes vs. type 1 diabetes ( 30254083) Latent autoimmune diabetes vs. type 2 diabetes ( 30254083) LDL cholesterol levels ( 32203549) Lung cancer in ever smokers ( 28604730) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 28166213 30804560) Lung function (low FEV1 vs high FEV1) ( 26423011) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Lymphocyte percentage of white cells ( 27863252) Lymphoma ( 23349640) Mean corpuscular volume ( 32888494) Medication use (antihistamines for systemic use) ( 31015401) Medication use (drugs used in diabetes) ( 31015401) Medication use (thyroid preparations) ( 31015401) Moderate to vigorous physical activity levels ( 29899525) Mosquito bite size ( 28199695) Multiple sclerosis ( 20453840) Multiple sclerosis (OCB status) ( 23472185) Myositis ( 26291516) Nephropathy ( 21399633) Neuromyelitis optica ( 29769526) Neuromyelitis optica (AQP4-IgG-positive) ( 29769526) Neutrophil count ( 32888494) Nodular sclerosis Hodgkin lymphoma ( 22086417) Oral cavity and pharyngeal cancer ( 27749845) Oral cavity cancer ( 32276964) Oropharynx cancer ( 27749845) Parkinson's disease ( 31660654) Peak expiratory flow ( 30804560) Peanut allergy ( 25710614) PEG-asparaginase hypersensitivity without enzyme activity in childhood acute lymphoblastic leukaemia ( 30450575) Plantar warts ( 28928442) Pneumonia ( 28928442) Primary biliary cholangitis ( 19458352 20639880) Primary biliary cirrhosis ( 22961000) Prostate cancer ( 23535732) Pulmonary function ( 21946350) Pulmonary function (smoking interaction) ( 23284291) Red blood cell count ( 29403010) Response to hepatitis B vaccine ( 29534301) Rheumatic heart disease ( 32488134) Rheumatoid arthritis ( 24782177 23918589) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Scarlet fever ( 28928442) Schizophrenia ( 30285260) Self-reported allergy ( 23817569) Sero-negative rheumatoid arthritis ( 28706201) Serum IgE levels ( 25488688) Serum uric acid levels ( 30993211) Shingles ( 28928442) SjÃ¶gren's syndrome ( 24097067 28076899) Strep throat ( 28928442) Systemic lupus erythematosus ( 24871463 26606652 26316170 26502338) Systemic sclerosis ( 20383147 21779181) Takayasu arteritis ( 23830517) Thyrotoxic hypokalemic periodic paralysis and Graves disease ( 31050781) Tonsillectomy ( 28928442) Triglyceride levels ( 32203549) Tuberculosis ( 29036319 28928442) Type 1 diabetes ( 31152121) Type 2 diabetes ( 30054458) Ulcerative colitis ( 24837172 28067908 23128233 19122664) Urate levels ( 31985003) White blood cell count ( 32888494) Yeast infection ( 28928442)
Interacting Genes		9 interacting genes: APLP1 CD74 CDK7 HLA-DQB1 IKBKG LRIF1 SH3GL2 TLE1 UNC119	5 interacting genes: CD4 CD74 HLA-DQA1 HLA-DQA2 INS
Entrez ID		3117	3119
HPRD ID		06765	05054
Ensembl ID		ENSG00000196735	ENSG00000179344
Uniprot IDs		A0A173ADG5 P01909 Q8MH44	P01920 Q5SU54 Q5Y7A9 Q5Y7D3 Q5Y7D6
PDB IDs		1JK8 1NBN 1S9V 1UVQ 2NNA 3PL6 4GG6 4OZF 4OZG 4OZH 4OZI 5KSA 5KSB 5KSU 5KSV 6MFF 6MFG 6U3M 6U3N	1JK8 1NBN 1S9V 1UVQ 2NNA 4D8P 4GG6 4OZF 4OZG 4OZH 4OZI 5KSU 5KSV 6DIG
Enriched GO Terms of Interacting Partners?
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