HLA-C and TAP2

Data Source:
HPRD (in vivo)

		HLA-C	TAP2
Description		major histocompatibility complex, class I, C	transporter 2, ATP binding cassette subfamily B member
Image
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Secretory Granule Membrane Phagocytic Vesicle Membrane Early Endosome Membrane MHC Class I Protein Complex Recycling Endosome Membrane Extracellular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Nuclear Speck Integral Component Of Endoplasmic Reticulum Membrane Phagocytic Vesicle Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane MHC Class I Peptide Loading Complex TAP Complex
	Molecular Function	Protein Binding Peptide Antigen Binding TAP Binding	Protein Binding ATP Binding ABC-type Peptide Antigen Transporter Activity ABC-type Peptide Transporter Activity ATPase Activity MHC Class Ib Protein Binding MHC Class I Protein Binding Peptide Antigen Binding ATPase-coupled Transmembrane Transporter Activity TAP1 Binding Tapasin Binding Peptide Transmembrane Transporter Activity
	Biological Process	Adaptive Immune Response Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Immune Response Viral Process Neutrophil Degranulation Regulation Of Immune Response Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway	Adaptive Immune Response Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Via ER Pathway, TAP-dependent Protein Transport Peptide Transport Viral Process Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Cytosol To Endoplasmic Reticulum Transport Peptide Antigen Transport Transmembrane Transport Anion Transmembrane Transport Vesicle Fusion With Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Membrane
Pathways		ER-Phagosome pathway ER-Phagosome pathway Endosomal/Vacuolar pathway Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Neutrophil degranulation Interferon gamma signaling Interferon alpha/beta signaling Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC	ER-Phagosome pathway ER-Phagosome pathway Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs
Diseases			Bare lymphocyte syndrome (BLS) type1 Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
GWAS		AIDS progression ( 19115949) Albumin-globulin ratio ( 29403010) Allergic rhinitis ( 30013184) Allergic sensitization ( 23817571) Asthma ( 27182965 31619474) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433 31619474) Asthma and major depressive disorder ( 31619474) Atopic dermatitis ( 23042114 25574825) Autism spectrum disorder or schizophrenia ( 28540026) Basophil count ( 32888494) Beta-2 microglubulin plasma levels ( 23417110) Birth weight ( 31043758) Blood cell traits (multivariate analysis) ( 31080455) Blood protein levels ( 29875488 28240269) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Cancer ( 27197191) Cancer (pleiotropy) ( 27197191) Cervical cancer ( 28806749) Chickenpox ( 28928442) Childhood ear infection ( 27182965 28928442) Cholesterol, total ( 26582766) Chronic hepatitis B infection ( 25802187) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Cold sores ( 28928442) Complement C3 and C4 levels ( 23028341) Coronary heart disease ( 22319020) Crohn's disease ( 23128233 26891255) Cutaneous psoriasis ( 26626624) Decline in glucose metabolism in posterior cingulate cortex ( 29130521) Drug-induced liver injury (flucloxacillin) ( 30661239) Eosinophil percentage of white cells ( 32888494) Estimated glomerular filtration rate ( 31015462) Feeling hurt ( 29500382) Feeling nervous ( 29500382) Feeling worry ( 29500382) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Height ( 25282103 23563607 31562340) Hematuria ( 30476138) Hematuria (mild) ( 30476138) Hematuria (moderate to severe) ( 30476138) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Hepatitis B ( 24162738) High light scatter reticulocyte percentage of red cells ( 32888494) HIV-1 control ( 21051598 20041166) HIV-1 susceptibility ( 23935489) HIV-1 viral setpoint ( 26039976) Hypothyroidism ( 22493691) IgE levels ( 24324648) IgG galactosylation phenotypes (multivariate analysis) ( 28878392) Inflammatory bowel disease ( 28067908) Itch intensity from mosquito bite adjusted by bite size ( 28199695) LDL cholesterol ( 26582766) Leprosy ( 32421744) Leukoderma in response to rhododendrol ( 32558222) Lung cancer ( 28604730) Lymphocyte counts ( 32888494 27863252) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010) Mean platelet volume ( 32888494) Monocyte count ( 29403010 32888494) Monocyte percentage of white cells ( 32888494) Myeloid white cell count ( 27863252) Myositis ( 26291516) Nasopharyngeal carcinoma ( 20512145) Neurociticism ( 29500382) Neuromyelitis optica ( 29769526) Neuromyelitis optica (AQP4-IgG-positive) ( 29769526) Neutrophil count ( 29403010 32888494 27863252) Nevirapine-induced hypersensitivity in HIV (Stevens-Johnson syndrome or toxic epidermal necrosis) ( 28062682) Non-albumin protein levels ( 29403010) Offspring birth weight ( 31043758) Perceived unattractiveness to mosquitoes ( 28199695) Plantar warts ( 28928442) Pneumonia ( 28928442) Protein quantitative trait loci ( 18464913) Psoriasis ( 30921485 20953188 20953190 23143594 18369459 18364390 19169254) Psoriasis vulgaris ( 26626624) Psoriatic arthritis ( 26626624 20953186) Red blood cell count ( 32888494) Response to hepatitis B vaccine ( 29534301) Reticulocyte count ( 27863252) Rosacea symptom severity ( 29771307) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Self-reported allergy ( 23817569) Serum albumin level ( 29403010) Setpoint viral load in HIV-1 infection ( 26553974) Severity of facial solar lentigines ( 27327535) Shingles ( 28928442) Small cell lung carcinoma ( 28604730) Squamous cell lung carcinoma ( 28604730) Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN) ( 21912425) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic lupus erythematosus ( 28714469) Takayasu arteritis ( 25604533) Tonsillectomy ( 27182965 28928442) Tuberculosis ( 28928442) Ulcerative colitis ( 28067908) Vitiligo ( 20526339) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) White blood cell count ( 29403010 32888494 27863252 21738480 28158719) White blood cell count (basophil) ( 29403010) White blood cell count (lymphocyte) ( 28158719)	Asthma ( 31619474) Asthma and major depressive disorder ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Composite immunoglobulin trait (IgA/IgG) ( 28628107) Hemoglobin levels ( 32327693) IgA nephropathy ( 25305756) Lymphocyte counts ( 32888494) Lymphoma ( 23349640) Monocyte count ( 32888494) Nephropathy ( 21399633) Platelet distribution width ( 32888494) Pubertal anthropometrics ( 23449627) Response to hepatitis B vaccine ( 29534301) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Urate levels in lean individuals ( 25811787)
Interacting Genes		24 interacting genes: B2M BATF2 CALR CD8A CDC25A GPR182 GPR37 HSPA5 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS2 KIR2DS4 LILRB1 LILRB2 MAPK8IP2 NPSR1 OPRL1 PRRG4 TANK TAP2 TAPBP YBX1	9 interacting genes: APP HLA-C HLA-G PSMB5 PSMB8 PSMG3 RBM18 TAP1 TAPBP
Entrez ID		3107	6891
HPRD ID		00829	01360
Ensembl ID		ENSG00000204525	ENSG00000204267
Uniprot IDs		O19617 P10321 Q6R739 Q95HC2	Q03519 Q5JNW1 Q9UP03 X5CMH5
PDB IDs		1EFX 1IM9 1QQD 3BZF 4NT6 5VGD 5VGE 5W67 5W69 5W6A 6JTO	5U1D
Enriched GO Terms of Interacting Partners?
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