HK2 and SLC2A4

Data Source:
HPRD (in vivo)

		HK2	SLC2A4
Description		hexokinase 2	solute carrier family 2 member 4
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Centrosome Cytosol Plasma Membrane Membrane Sarcoplasmic Reticulum Intracellular Membrane-bounded Organelle	Multivesicular Body Trans-Golgi Network Cytosol Plasma Membrane Integral Component Of Plasma Membrane Clathrin-coated Pit External Side Of Plasma Membrane Endomembrane System Vesicle Membrane Membrane Sarcoplasmic Reticulum Clathrin-coated Vesicle Trans-Golgi Network Transport Vesicle T-tubule Cytoplasmic Vesicle Membrane Insulin-responsive Compartment Sarcolemma Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome Presynapse
	Molecular Function	Glucokinase Activity Hexokinase Activity Protein Binding ATP Binding Glucose Binding Fructokinase Activity Mannokinase Activity	Glucose Transmembrane Transporter Activity Protein Binding D-glucose Transmembrane Transporter Activity
	Biological Process	Response To Hypoxia Cellular Glucose Homeostasis Response To Ischemia Fructose 6-phosphate Metabolic Process Glycolytic Process Lactation Apoptotic Mitochondrial Changes Negative Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Angiogenesis Regulation Of Glucose Import Carbohydrate Phosphorylation Glucose 6-phosphate Metabolic Process Canonical Glycolysis Establishment Of Protein Localization To Mitochondrion Maintenance Of Protein Location In Mitochondrion Positive Regulation Of Autophagy Of Mitochondrion In Response To Mitochondrial Depolarization Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of Reactive Oxygen Species Metabolic Process	Carbohydrate Metabolic Process Learning Or Memory Short-term Memory Long-term Memory Amylopectin Biosynthetic Process Positive Regulation Of Brain-derived Neurotrophic Factor Receptor Signaling Pathway Cellular Response To Insulin Stimulus Glucose Homeostasis Glucose Import In Response To Insulin Stimulus Response To Ethanol Glucose Import Brown Fat Cell Differentiation Cellular Response To Tumor Necrosis Factor Cellular Response To Hypoxia Cellular Response To Osmotic Stress Regulation Of Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Transport Across Blood-brain Barrier Glucose Transmembrane Transport
Pathways		Glycolysis	Translocation of SLC2A4 (GLUT4) to the plasma membrane Cellular hexose transport Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases
GWAS		Femoral neck bone geometry ( 22087292)	Apolipoprotein B levels ( 32203549) Birth weight ( 23202124 31043758) Diastolic blood pressure ( 28135244) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Medication use (diuretics) ( 31015401) Metabolite levels ( 22286219) Offspring birth weight ( 31043758) Pulse pressure ( 28135244) Systolic blood pressure ( 30578418) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		9 interacting genes: ENO1 MAGEA12 PRKCE PTGDS SLC2A4 SUMO2 UBQLN1 UBQLN4 ZBTB17	40 interacting genes: ACOX1 ACTN1 ACTN4 AKT2 AP1M1 ARF3 ARFIP1 BSG C1QTNF5 CCDC116 CFL1 CREB3 CTSD DAXX DLD EHD2 ESYT2 FAR1 FKBP10 GAPDH HADH HK2 HSP90AA1 IDH2 KLHL41 LNPEP MAP1S MVP P3H1 P3H4 PDIA6 PRKAR1A PSMD7 RAB7A SERPINH1 SRFBP1 STRN3 UBA52 UBE2I UBE2N
Entrez ID		3099	6517
HPRD ID		03080	00688
Ensembl ID		ENSG00000159399	ENSG00000181856
Uniprot IDs		P52789	P14672
PDB IDs		2NZT 5HEX 5HFU 5HG1
Enriched GO Terms of Interacting Partners?
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