HINT1 and MITF

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		HINT1	MITF
Description		histidine triad nucleotide binding protein 1	melanocyte inducing transcription factor
Image
GO Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Extracellular Exosome	Chromatin Nucleus Nucleoplasm Cytoplasm Protein-containing Complex
	Molecular Function	Nucleotide Binding Protein Kinase C Binding Protein Binding Hydrolase Activity Adenosine 5'-monophosphoramidase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding Protein Binding Protein Dimerization Activity E-box Binding
	Biological Process	Regulation Of Transcription, DNA-templated Signal Transduction Purine Ribonucleotide Catabolic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator	Negative Regulation Of Transcription By RNA Polymerase II Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Gene Expression Osteoclast Differentiation Melanocyte Differentiation Negative Regulation Of Cell Migration Regulation Of Cell Population Proliferation Camera-type Eye Development Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process Cell Fate Commitment Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Bone Remodeling Protein-containing Complex Assembly Positive Regulation Of DNA-templated Transcription, Initiation Regulation Of RNA Biosynthetic Process
Pathways			SUMOylation of transcription factors
Drugs		Adenosine phosphate Guanosine-5'-Monophosphate 5'-O-(N-Ethyl-Sulfamoyl)Adenosine Adenosine-5'-ditungstate 8-Bromo-Adenosine-5'-Monophosphate
Diseases			Ocular albinism; Ocular albinism, type I (OA1); Waardenburg syndrome, type II (WS2-OA) Waardenburg syndrome (WS) Malignant melanoma
GWAS		Blood protein levels ( 29875488) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)	Apolipoprotein B levels ( 32203549) Blond vs. brown/black hair color ( 30531825) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Carotid intima media thickness x smoking interaction ( 32117412) Chronotype ( 30696823) Circulating fibroblast growth factor 23 levels ( 30217807) Coronary artery disease ( 33020668) Cortical surface area (MOSTest) ( 32665545) Cutaneous malignant melanoma ( 32341527) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Neutrophil count ( 32888494) Nevus count or cutaneous melanoma ( 32341527) Platelet count ( 32888494) Plateletcrit ( 32888494) Pulse pressure ( 27841878) QRS complex (12-leadsum) ( 27659466) Red blood cell count ( 32888494 27863252) Renal underexcretion gout ( 32238385) Severe influenza A (H1N1) infection ( 26379185) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27841878) Triglyceride levels ( 32203549)
Interacting Genes		6 interacting genes: CDC16 CPSF7 ERBB3 MITF SP1 TRIM29	30 interacting genes: ADRB2 APP CTNNB1 EBP EP300 FBXO7 FOS GSK3B HINT1 HK3 LEF1 MAPK1 MAPK14 MARK3 OTX2 PATZ1 PAX3 PAX6 PIAS1 PIAS2 PIAS3 PSMD14 RPS6KA1 SPI1 STUB1 SUMO1 TFE3 TFEB TFEC UBE2I
Entrez ID		3094	4286
HPRD ID		03204	01138
Ensembl ID		ENSG00000169567	ENSG00000187098
Uniprot IDs		A0A384NPU2 P49773	A0A087WXU1 B4DNC7 O75030 Q8WYR3
PDB IDs		1AV5 1KPA 1KPB 1KPC 1KPE 1KPF 3TW2 4EQE 4EQG 4EQH 4ZKL 4ZKV 5ED3 5ED6 5EMT 5I2E 5I2F 5IPB 5IPC 5IPD 5IPE 5KLY 5KLZ 5KM0 5KM1 5KM2 5KM3 5KM4 5KM6 5KMA 5KMB 5KMC 5O8I 5WA8 5WA9 5WAA 6B42 6G9Z 6J53 6J58 6J5S 6J5Z 6J64 6J65 6N3V 6N3W 6N3X 6N3Y 6YQM	4C7N
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?