H1-4 and CBX3

Data Source:
BioGRID (x-ray crystallography)
HPRD (in vitro)

		H1-4	CBX3
Description		H1.4 linker histone, cluster member	chromobox 3
Image
GO Annotations	Cellular Component	Nucleosome Heterochromatin Nucleus	Chromosome, Centromeric Region Condensed Chromosome, Centromeric Region Chromosome, Telomeric Region Chromatin Euchromatin Heterochromatin Nucleus Nuclear Envelope Nuclear Inner Membrane Nucleoplasm Pericentric Heterochromatin Spindle Senescence-associated Heterochromatin Focus RNA Polymerase II Transcription Regulator Complex Site Of DNA Damage
	Molecular Function	Double-stranded DNA Binding RNA Binding Calcium Ion Binding Protein Binding ATP Binding GTP Binding AMP Binding Chromatin DNA Binding Nucleosomal DNA Binding DATP Binding ADP Binding	Protein Binding Transcription Factor Binding Enzyme Binding Protein Domain Specific Binding Identical Protein Binding Histone Methyltransferase Binding
	Biological Process	Nucleosome Assembly Nucleosome Positioning Chromosome Condensation Negative Regulation Of Chromatin Silencing Negative Regulation Of DNA Recombination	Chromatin Remodeling Cellular Response To DNA Damage Stimulus Negative Regulation Of Transcription, DNA-templated Rhythmic Process Negative Regulation Of G0 To G1 Transition Cellular Response To Dexamethasone Stimulus
Pathways		Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)	ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression RNA Polymerase I Promoter Escape Transcriptional Regulation by E2F6
Drugs		Copper
Diseases
GWAS			Metabolite levels ( 23823483) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		6 interacting genes: CBX1 CBX3 CBX5 IL7R IRAK4 PRKCA	46 interacting genes: ADAMTSL4 ADNP2 ARL5A ATXN7L2 AURKA AURKB BARD1 CACNB4 CBX1 CBX5 CDC42 DNMT3B DSN1 GDF15 H1-4 H3-4 H3C1 H4C1 HECW2 HIPK2 HTR2C KLF11 L3MBTL1 LAP3 LBR LRIF1 MGA MIS12 MKI67 MRPL12 NSD3 NSL1 PIM1 PRR14 RAD54L2 SP100 STK16 SUV39H1 TAF4 TRIM24 TRIM28 VHL ZNF10 ZNF280C ZNF280D ZNF496
Entrez ID		3008	11335
HPRD ID		07513	05130
Ensembl ID		ENSG00000168298	ENSG00000122565
Uniprot IDs		A3R0T8 P10412	A4D177 Q13185
PDB IDs		3TZD 5JJZ 6H8P	2L11 3DM1 3KUP 3TZD 5T1I 6HW2
Enriched GO Terms of Interacting Partners?
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