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RPA4 and MSH3
Data Source:
BioGRID
(pull down)
RPA4
MSH3
Description
replication protein A4
mutS homolog 3
Image
No pdb structure
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
DNA Replication Factor A Complex
Site Of Double-strand Break
Nucleus
Nucleoplasm
Membrane
Mismatch Repair Complex
MutSbeta Complex
Molecular Function
Single-stranded DNA Binding
Protein Binding
Single-stranded DNA Binding
Protein Binding
ATP Binding
DNA-dependent ATPase Activity
Enzyme Binding
Mismatched DNA Binding
DNA Insertion Or Deletion Binding
Guanine/thymine Mispair Binding
Dinucleotide Insertion Or Deletion Binding
Single Guanine Insertion Binding
Dinucleotide Repeat Insertion Binding
Oxidized Purine DNA Binding
Protein Homodimerization Activity
Biological Process
DNA Damage Checkpoint
G1/S Transition Of Mitotic Cell Cycle
Double-strand Break Repair Via Homologous Recombination
DNA Replication
DNA Replication Initiation
Nucleotide-excision Repair
Nuclear DNA Replication
Meiotic Mismatch Repair
Removal Of Nonhomologous Ends
DNA Repair
Mismatch Repair
Mitotic Recombination
Reciprocal Meiotic Recombination
Somatic Recombination Of Immunoglobulin Gene Segments
Replication Fork Arrest
Maintenance Of DNA Repeat Elements
Negative Regulation Of DNA Recombination
Positive Regulation Of Helicase Activity
Pathways
Activation of the pre-replicative complex
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
Defective Mismatch Repair Associated With MSH3
Defective Mismatch Repair Associated With MSH2
Drugs
Diseases
Colorectal cancer
GWAS
Brain morphology (MOSTest) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
HDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes (
28736931
)
Huntington's disease progression (
28642124
)
Idiopathic downbeat nystagmus (
32157568
)
Subcortical volume (MOSTest) (
32665545
)
Interacting Genes
8 interacting genes:
APP
MSH2
MSH3
MUTYH
PTRHD1
RPA1
RPA3
XPA
14 interacting genes:
BARD1
BRCA1
EXO1
HUS1
MLH1
MSH2
PCNA
RAD1
RAD9A
RCHY1
RPA4
SUMO2
TSC22D2
XPA
Entrez ID
29935
4437
HPRD ID
06591
02931
Ensembl ID
ENSG00000204086
ENSG00000113318
Uniprot IDs
Q13156
P20585
PDB IDs
3THW
3THX
3THY
3THZ
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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