GUK1 and NLGN3

Data Source:
BioGRID (two hybrid)

		GUK1	NLGN3
Description		guanylate kinase 1	neuroligin 3
Image			No pdb structure
GO Annotations	Cellular Component	Photoreceptor Inner Segment Cytosol	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Endocytic Vesicle Synapse Excitatory Synapse Spanning Component Of Membrane Presynapse Symmetric, GABA-ergic, Inhibitory Synapse Asymmetric, Glutamatergic, Excitatory Synapse Integral Component Of Postsynaptic Membrane
	Molecular Function	Guanylate Kinase Activity Protein Binding ATP Binding	Protein Binding Signaling Receptor Activity Neurexin Family Protein Binding Cell Adhesion Molecule Binding Scaffold Protein Binding
	Biological Process	Purine Nucleotide Metabolic Process DGDP Biosynthetic Process Xenobiotic Metabolic Process Nucleobase-containing Small Molecule Interconversion Phosphorylation GMP Metabolic Process GDP Metabolic Process	Regulation Of Respiratory Gaseous Exchange By Nervous System Process Receptor-mediated Endocytosis Neuron Cell-cell Adhesion Chemical Synaptic Transmission Synapse Assembly Learning Adult Behavior Social Behavior Synaptic Vesicle Endocytosis Axon Extension Modulation Of Chemical Synaptic Transmission Synapse Organization Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Rhythmic Synaptic Transmission Inhibitory Postsynaptic Potential Vocalization Behavior Postsynaptic Membrane Assembly Presynaptic Membrane Assembly Presynapse Assembly Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of AMPA Receptor Activity
Pathways		Abacavir metabolism Interconversion of nucleotide di- and triphosphates	Neurexins and neuroligins Neurexins and neuroligins
Drugs		Guanosine-5'-Monophosphate
Diseases
GWAS		Coronary artery disease ( 29212778)	Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Prostate cancer ( 25217961)
Interacting Genes		2 interacting genes: HNRNPD NLGN3	55 interacting genes: ALPP AP2A2 ATF4 C1orf122 C1QA CCAR2 CGB3 CTSD DLG2 DLG3 DLG4 DPEP2 EBPL EFS FANCG FBLN1 FHOD1 FKBP1A FLNA GDF15 GUK1 HID1 ITPRIP LGALS1 MAN2C1 MAP1S MEOX2 MIEN1 NFATC4 NRDC NRXN1 NRXN2 NRXN3 OAZ1 OR1F12 PKIB PLB1 PLCB4 PRDX2 PSAP PSG1 PSG11 PSG3 PSG4 PSG5 QARS1 SPAG5 SPINT1 SSR4 TNNT3 TRIM33 TXNIP UBQLN1 UBXN6 UQCRC1
Entrez ID		2987	54413
HPRD ID		00755	02275
Ensembl ID		ENSG00000143774	ENSG00000196338
Uniprot IDs		A0A024R3U5 Q16774 Q6IBG8	B7Z3P8 Q4G160 Q6MZK0 Q9NZ94 X5D2P6 X5D7L6 X5DNV3
PDB IDs		6NUI
Enriched GO Terms of Interacting Partners?
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