ICOS and ADAM23

Data Source:
BioGRID (affinity chromatography technology)

		ICOS	ADAM23
Description		inducible T cell costimulator	ADAM metallopeptidase domain 23
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Membrane	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Glutamatergic Synapse Integral Component Of Presynaptic Membrane
	Molecular Function	Protein Binding	Metalloendopeptidase Activity Integrin Binding Protein Binding Metallopeptidase Activity
	Biological Process	T Cell Tolerance Induction Immune Response T Cell Costimulation Positive Regulation Of Protein Kinase B Signaling Cell-cell Adhesion	Proteolysis Cell Adhesion Central Nervous System Development Cellular Response To Leukemia Inhibitory Factor
Pathways			LGI-ADAM interactions
Drugs
Diseases		Common variable immunodeficiency (CVID), including the following four diseases: Inducible T Cell costimulator (ICOS) defect; TACI defect; CD19 defect; BAFFR defect
GWAS		Alopecia areata ( 20596022 25608926) Aluminium levels ( 26025379) Body mass index ( 28892062) Celiac disease ( 20190752) Diastolic blood pressure ( 30224653) Hypothyroidism ( 27182965) Idiopathic dilated cardiomyopathy ( 29495422) Inflammatory bowel disease ( 26192919) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Primary biliary cholangitis ( 28425483) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596) Ulcerative colitis ( 26192919)	Bipolar disorder and schizophrenia ( 22688191) Blood protein levels ( 30072576 29875488) Body mass index ( 28892062 25673413) Childhood body mass index ( 26604143) Fish- and plant-related diet ( 32066663) Neurological blood protein biomarker levels ( 31320639) Tonsillectomy ( 27182965 28928442) Trunk fat mass ( 28552196) Waist-hip ratio ( 28552196)
Interacting Genes		4 interacting genes: ICOSLG NUFIP2 RC3H1 WIF1	1 interacting genes: PRNP
Entrez ID		29851	8745
HPRD ID		09196	04752
Ensembl ID		ENSG00000163600	ENSG00000114948
Uniprot IDs		Q53QY6 Q9Y6W8	A0A024R3W8 E7EWD3 O75077
PDB IDs		6X4G 7JOO
Enriched GO Terms of Interacting Partners?
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