ICOS and BRCC3

Data Source:
HPRD (in vitro, in vivo)

		ICOS	BRCC3
Description		inducible T cell costimulator	BRCA1/BRCA2-containing complex subunit 3
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GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Membrane	Ubiquitin Ligase Complex Nuclear Ubiquitin Ligase Complex Spindle Pole Nucleus Nucleoplasm Cytoplasm Cytosol BRCA1-A Complex BRISC Complex
	Molecular Function	Protein Binding	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Metallopeptidase Activity Enzyme Regulator Activity Polyubiquitin Modification-dependent Protein Binding Metal Ion Binding Lys63-specific Deubiquitinase Activity Isopeptidase Activity
	Biological Process	T Cell Tolerance Induction Immune Response T Cell Costimulation Positive Regulation Of Protein Kinase B Signaling Cell-cell Adhesion	Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Cell Cycle Response To X-ray Response To Ionizing Radiation Protein Deubiquitination Protein Phosphopantetheinylation Positive Regulation Of DNA Repair Regulation Of Catalytic Activity Cell Division Protein K63-linked Deubiquitination Histone H2A K63-linked Deubiquitination Signal Transduction Involved In G2 DNA Damage Checkpoint
Pathways			Metalloprotease DUBs Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint
Drugs			Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		Common variable immunodeficiency (CVID), including the following four diseases: Inducible T Cell costimulator (ICOS) defect; TACI defect; CD19 defect; BAFFR defect
GWAS		Alopecia areata ( 20596022 25608926) Aluminium levels ( 26025379) Body mass index ( 28892062) Celiac disease ( 20190752) Diastolic blood pressure ( 30224653) Hypothyroidism ( 27182965) Idiopathic dilated cardiomyopathy ( 29495422) Inflammatory bowel disease ( 26192919) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Primary biliary cholangitis ( 28425483) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596) Ulcerative colitis ( 26192919)	Venous thromboembolism ( 31676865)
Interacting Genes		4 interacting genes: ICOSLG NUFIP2 RC3H1 WIF1	11 interacting genes: ANKRD11 BRCA1 FANCG IFNAR1 NUMA1 SHMT2 SNAPC5 SUMO2 UBC UBE2D1 UIMC1
Entrez ID		29851	79184
HPRD ID		09196	06465
Ensembl ID		ENSG00000163600	ENSG00000185515
Uniprot IDs		Q53QY6 Q9Y6W8	P46736
PDB IDs		6X4G 7JOO	6H3C 6R8F
Enriched GO Terms of Interacting Partners?
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