GTF2A2 and GTF2A1

Data Source:
BioGRID (two hybrid)
HPRD (in vitro)

		GTF2A2	GTF2A1
Description		general transcription factor IIA subunit 2	general transcription factor IIA subunit 1
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GO Annotations	Cellular Component	Nucleoplasm Transcription Factor TFIID Complex Transcription Factor TFIIA Complex Cell Junction	Nucleoplasm Transcription Factor TFIID Complex Transcription Factor TFIIA Complex Cytosol Transcription Preinitiation Complex
	Molecular Function	RNA Polymerase II Repressing Transcription Factor Binding Protein Binding Transcription Factor Binding RNA Polymerase II General Transcription Initiation Factor Activity TBP-class Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity	RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Repressing Transcription Factor Binding DNA Binding Protein Binding Transcription Factor Binding RNA Polymerase II General Transcription Initiation Factor Activity TBP-class Protein Binding Protein Heterodimerization Activity
	Biological Process	Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Viral Process SnRNA Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly	Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter SnRNA Transcription By RNA Polymerase II
Pathways		HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome RNA Polymerase II Pre-transcription Events RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance Estrogen-dependent gene expression	HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome RNA Polymerase II Pre-transcription Events RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance Estrogen-dependent gene expression
Drugs
Diseases
GWAS		Macular thickness ( 30535121)	Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Neutrophil count ( 32888494) Night sleep phenotypes ( 27126917) Thyroid stimulating hormone levels ( 32769997) White blood cell count ( 32888494)
Interacting Genes		9 interacting genes: GTF2A1 GTF2A1L GTF2E1 HSF1 PTPN11 TAF4 TBP TBPL1 TRIM7	26 interacting genes: BCL3 BIRC7 CREB1 CSNK2A1 CSNK2A2 GTF2A2 GTF2E1 GTF2E2 GTF2F1 HMGB1 NCOA6 NFYA PRR20A PRR20B PRR20C PRR20D PRR20E PSMC6 SP4 TAF1 TAF4 TAF4B TASP1 TBP TBPL1 TRIP4
Entrez ID		2958	2957
HPRD ID		02747	02748
Ensembl ID		ENSG00000140307	ENSG00000165417
Uniprot IDs		A0A024R5Z5 B2R506 P52657	P52655
PDB IDs		1NVP 5FUR 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 5M4S 6MZM 6O9L	1NVP 5FUR 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 5M4S 6MZM 6O9L
Enriched GO Terms of Interacting Partners?
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