GSS and GSTZ1

Data Source:
HPRD (in vitro)

		GSS	GSTZ1
Description		glutathione synthetase	glutathione S-transferase zeta 1
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GO Annotations	Cellular Component	Cytosol Extracellular Exosome	Mitochondrion Mitochondrial Matrix Cytosol
	Molecular Function	Magnesium Ion Binding Glutathione Synthase Activity Protein Binding ATP Binding Glycine Binding Identical Protein Binding Protein Homodimerization Activity Glutathione Binding	Glutathione Transferase Activity Glutathione Peroxidase Activity Protein Binding Maleylacetoacetate Isomerase Activity Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Cellular Amino Acid Metabolic Process Glutathione Biosynthetic Process Response To Oxidative Stress Nervous System Development Aging Response To Xenobiotic Stimulus Response To Nutrient Levels Response To Tumor Necrosis Factor Response To Amino Acid Response To Cadmium Ion	L-phenylalanine Catabolic Process Tyrosine Catabolic Process Glutathione Metabolic Process Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Cellular Oxidant Detoxification Glutathione Derivative Biosynthetic Process
Pathways		Glutathione synthesis and recycling Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)	Glutathione conjugation Regulation of pyruvate dehydrogenase (PDH) complex Tyrosine catabolism
Drugs		Glutathione Glycine Cysteine gamma-Glutamylcysteine Phosphoaminophosphonic Acid-Adenylate Ester Acetylcysteine Copper	Glutathione 1,4-Dithiothreitol Dichloroacetic acid Glycerin
Diseases		Anemia due to disorders of glutathione metabolism, including: Glucose-6-phosphate dehydrogenase (G6PD) deficiency; Glutathione peroxidase (GPX) deficiency; Gamma-glutamylcysteine synthetase (GCLC) deficiency; Glutathione synthetase (GSS) deficiency
GWAS		Bipolar disorder ( 31043756) Blood protein levels ( 28240269) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163) Fish- and plant-related diet ( 32066663) Height ( 28552196) Hemostatic factors and hematological phenotypes ( 22443383) QRS complex (Cornell) ( 27659466) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		2 interacting genes: GSTZ1 TERF1	9 interacting genes: CLVS2 GORASP2 GSS PLEKHG4 PPP1CC QARS1 TCP11 TRAF2 ZMYND12
Entrez ID		2937	2954
HPRD ID		03000	04785
Ensembl ID		ENSG00000100983	ENSG00000100577
Uniprot IDs		P48637 V9HWJ1	A0A0A0MR33 A0A0C4DFM0 O43708
PDB IDs		2HGS	1FW1
Enriched GO Terms of Interacting Partners?
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