GRM7 and TUBA3C

Data Source:
HPRD (in vitro, in vivo)

		GRM7	TUBA3C
Description		glutamate metabotropic receptor 7	tubulin alpha 3c
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Cortex Integral Component Of Membrane Axon Dendrite Asymmetric Synapse Dendritic Shaft Receptor Complex Postsynaptic Membrane Presynaptic Active Zone	Nucleus Cytoplasm Microtubule
	Molecular Function	Adenylate Cyclase Inhibiting G Protein-coupled Glutamate Receptor Activity Group III Metabotropic Glutamate Receptor Activity Glutamate Receptor Activity Adenylate Cyclase Inhibitor Activity Serine Binding	GTPase Activity Structural Constituent Of Cytoskeleton GTP Binding
	Biological Process	Behavioral Fear Response G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Sensory Perception Of Sound Negative Regulation Of Glutamate Secretion Regulation Of Cyclase Activity Regulation Of Synaptic Transmission, Glutamatergic	Microtubule Cytoskeleton Organization Mitotic Cell Cycle
Pathways		G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors)	Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Cilium Assembly Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Cilium Assembly Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins
Drugs		Glutamic acid
Diseases
GWAS		Acute kidney injury in coronary artery bypass surgery (creatinine rise) ( 26083657) Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) ( 23648065) Airway imaging phenotypes ( 26030696) Chronotype ( 30696823) Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 26876947) Daytime sleep phenotypes ( 27126917) Diastolic blood pressure ( 30224653) Early response to risperidone in schizophrenia ( 26856250) Major depressive disorder (broad) ( 20038947) Night sleep phenotypes ( 27126917) Orofacial clefts ( 22419666) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Panic disorder ( 19165232) Personality traits in bipolar disorder ( 21368711) Plasma clusterin levels ( 26545630) Platelet reactivity in response to clopidogrel treatment ( 32472697) Recurrent major depressive disorder ( 29317602) Response to fenofibrate (total cholesterol levels) ( 27002377) Systemic sclerosis ( 30247649) Telomere length ( 30185882) Urate levels in lean individuals ( 25811787) Urinary albumin excretion ( 32277301) Uterine fibroid number (single vs multiple) ( 30196971) Visceral adipose tissue adjusted for BMI ( 22589738)	Coronary artery aneurysm in Kawasaki disease ( 27171184) Fasting blood insulin (BMI interaction) ( 22581228) Joint mobility (Beighton score) ( 27182965)
Interacting Genes		14 interacting genes: CALM1 CALM2 CALM3 FLNA GNAQ GRIP1 GRIPAP1 PICK1 SDCBP TUBA1A TUBA1B TUBA3C TUBA4A TUBA8	12 interacting genes: DYNLL1 DYNLT1 FYN GRM7 MYC NMI PFDN5 PXN SIAH1 TUBG1 UBC YWHAQ
Entrez ID		2917	7278
HPRD ID		04979	03958
Ensembl ID		ENSG00000196277	ENSG00000198033
Uniprot IDs		B2R693 B9EGG9 Q14831 Q59G95	P0DPH7 P0DPH8 Q1ZYQ1
PDB IDs		3MQ4 5C5C
Enriched GO Terms of Interacting Partners?
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