STXBP6 and SNAP25

Data Source:
HPRD (in vitro, in vivo)

		STXBP6	SNAP25
Description		syntaxin binding protein 6	synaptosome associated protein 25
Image		No pdb structure
GO Annotations	Cellular Component	Exocyst Plasma Membrane Adherens Junction Integral Component Of Membrane	Photoreceptor Inner Segment Cytoplasm Trans-Golgi Network Cytosol Cytoskeleton Plasma Membrane Synaptic Vesicle Voltage-gated Potassium Channel Complex Membrane Growth Cone BLOC-1 Complex SNARE Complex Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Vesicle Specific Granule Membrane Somatodendritic Compartment Presynaptic Membrane Neuron Projection Perinuclear Region Of Cytoplasm Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Tertiary Granule Membrane Postsynapse Glutamatergic Synapse
	Molecular Function	Phosphatidylinositol-4,5-bisphosphate Binding Cadherin Binding Involved In Cell-cell Adhesion	Voltage-gated Potassium Channel Activity SNAP Receptor Activity Protein Binding Syntaxin-1 Binding Syntaxin Binding Calcium-dependent Protein Binding
	Biological Process	Exocytosis Golgi To Plasma Membrane Transport Regulation Of SNARE Complex Assembly Negative Regulation Of Exocytosis Cell-cell Adhesion	Neurotransmitter Uptake Exocytosis Vesicle Fusion Chemical Synaptic Transmission Neurotransmitter Secretion Locomotory Behavior Associative Learning Regulation Of Neuron Projection Development Glutamate Secretion Synaptic Vesicle Exocytosis Synaptic Vesicle Docking Synaptic Vesicle Priming Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Neutrophil Degranulation Regulation Of Insulin Secretion Long-term Synaptic Potentiation Potassium Ion Transmembrane Transport Exocytic Insertion Of Neurotransmitter Receptor To Postsynaptic Membrane Neurotransmitter Receptor Internalization
Pathways			Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Regulation of insulin secretion Other interleukin signaling Toxicity of botulinum toxin type A (botA) Toxicity of botulinum toxin type C (botC) Toxicity of botulinum toxin type E (botE) Neutrophil degranulation GABA synthesis, release, reuptake and degradation
Drugs			Botulinum toxin type A
Diseases
GWAS		Adult body size ( 32376654) Body mass index ( 26961502 28892062 25673413 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Cognitive decline rate in late mild cognitive impairment ( 26252872) Eosinophil counts ( 32888494 27863252) Granulocyte count ( 27863252) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference ( 28552196 25673412) Hippocampal volume ( 21116278) Immature fraction of reticulocytes ( 32888494) Lymphocyte percentage of white cells ( 32888494 27863252) Microalbuminuria in type 1 diabetes ( 31537649) Monocyte count ( 29403010 27863252) Monocyte percentage of white cells ( 32888494) Myeloid white cell count ( 27863252) Neuritic plaque ( 31497858) Neutrophil count ( 29403010 32888494 27863252) Neutrophil percentage of white cells ( 32888494) Overweight status ( 25133637) Peanut allergy ( 29030101) Platelet count ( 32888494) Plateletcrit ( 32888494) Protein level change in low calorie diet obesity intervention ( 29234017) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Subcutaneous adipose tissue ( 22589738) Sum basophil neutrophil counts ( 27863252) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Waist circumference ( 25673412) White blood cell count ( 29403010 32888494 27863252) White blood cell types ( 21738478) Zinc levels ( 26025379)	Brain imaging measurements (variance) ( 32047264) Cardiac hypertrophy ( 21348951) Psychosis proneness (hypomanic personality scale and revised social anhedonia scale) ( 28525603)
Interacting Genes		3 interacting genes: SNAP25 STX1A STX4	39 interacting genes: APP CENPF CPLX1 DNM1 FBXO7 GOSR1 HGS ITSN1 KCNB1 KIF5B NAPA PRKACA PRKCA PRRT2 RIMS1 SCAMP1 SNAPIN SRCIN1 STX11 STX12 STX19 STX1A STX2 STX3 STX4 STX5 STXBP6 SYT1 SYT3 SYT9 TRIM9 UQCC2 VAMP2 VAMP7 VAMP8 WASHC3 ZDHHC17 ZNF177 ZNF559-ZNF177
Entrez ID		29091	6616
HPRD ID		06410	02637
Ensembl ID		ENSG00000168952	ENSG00000132639
Uniprot IDs		Q8NFX7	P60880
PDB IDs			1KIL 1XTG 2N1T 3DDA 3DDB 3RK2 3RK3 3RL0 3ZUR 5W7I 5W7J 6JLH
Enriched GO Terms of Interacting Partners?
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