CHMP4A and CHMP6

Data Source:
HPRD (two hybrid)

		CHMP4A	CHMP6
Description		charged multivesicular body protein 4A	charged multivesicular body protein 6
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GO Annotations	Cellular Component	ESCRT III Complex Nucleus Cytoplasm Endosome Multivesicular Body Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane Coat Midbody Cytoplasmic Vesicle Membrane Late Endosome Membrane	ESCRT III Complex Multivesicular Body Cytosol Endosome Membrane Membrane Late Endosome Membrane Extracellular Exosome
	Molecular Function	Protein Binding Lipid Binding Identical Protein Binding Protein Homodimerization Activity ATPase Binding	Protein Binding Protein-containing Complex Binding Protein N-terminus Binding
	Biological Process	Posttranslational Protein Targeting To Endoplasmic Reticulum Membrane Vesicle Budding From Membrane Nucleus Organization Mitotic Metaphase Plate Congression Membrane Invagination Endosomal Transport Macroautophagy Viral Life Cycle Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Protein Polymerization Midbody Abscission Plasma Membrane Tubulation Negative Regulation Of Neuron Death Negative Regulation Of Autophagosome Assembly	Vesicle Budding From Membrane Nucleus Organization Mitotic Metaphase Plate Congression Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Protein Transport Endosomal Transport Macroautophagy Viral Life Cycle Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Regulation Of Protein Catabolic Process Midbody Abscission Regulation Of Exosomal Secretion ESCRT III Complex Assembly
Pathways		Budding and maturation of HIV virion Macroautophagy Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy Sealing of the nuclear envelope (NE) by ESCRT-III Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex	Budding and maturation of HIV virion Macroautophagy Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy Sealing of the nuclear envelope (NE) by ESCRT-III Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex
Drugs
Diseases
GWAS
Interacting Genes		14 interacting genes: CC2D1A CDK13 CHMP3 CHMP4B CHMP4C CHMP5 CHMP6 NTAQ1 NUTF2 PDCD6IP STAMBP SYT17 TTC19 VPS4A	7 interacting genes: CHMP4A CHMP4B ELOF1 METTL9 SNF8 VPS25 VPS36
Entrez ID		29082	79643
HPRD ID		16597	08564
Ensembl ID		ENSG00000254505	ENSG00000176108
Uniprot IDs		Q9BY43	Q96FZ7
PDB IDs		3C3O 5MK1	2K3W 3HTU
Enriched GO Terms of Interacting Partners?
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