NDUFAF3 and UHMK1

Data Source:
BioGRID (two hybrid)

		NDUFAF3	UHMK1
Description		NADH:ubiquinone oxidoreductase complex assembly factor 3	U2AF homology motif kinase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Mitochondrial Inner Membrane	Nucleus Nucleoplasm Golgi Apparatus Axon Midbody Dendrite Cytoplasm Neuronal Ribonucleoprotein Granule
	Molecular Function	Protein Binding	RNA Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Transferase Activity Ribonucleoprotein Complex Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Mitochondrial Respiratory Chain Complex I Assembly	Cell Cycle Arrest Peptidyl-serine Phosphorylation Neuron Projection Development Positive Regulation Of Translational Initiation Protein Autophosphorylation Regulation Of Protein Export From Nucleus
Pathways		Complex I biogenesis	Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Drugs
Diseases		Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Blood protein levels ( 28240269) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Mood instability ( 31168069) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)	Bone mineral density (femoral neck) ( 27424934) Bone mineral density (total hip) ( 27424934) Discordance in emotional problems in monozygotic twins ( 27043157) Takayasu arteritis ( 25604533)
Interacting Genes		17 interacting genes: AGTRAP CABP2 CYSRT1 GEM GOLGA6L9 INCA1 KRT27 KRTAP10-3 LSM1 MBD3L1 NDUFAF4 POU2AF1 RBCK1 REL RNF146 SNRPA UHMK1	9 interacting genes: C1orf109 DEPDC1B LMO1 NDUFAF3 PAM RGS8 STMN1 TMSB4X TSGA10IP
Entrez ID		25915	127933
HPRD ID		16809	12318
Ensembl ID		ENSG00000178057	ENSG00000152332
Uniprot IDs		A4FU71 Q9BU61 Q9Y3Z0	Q8TAS1
PDB IDs
Enriched GO Terms of Interacting Partners?
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