IFT81 and TPCN1

Data Source:
BioGRID (proximity labelling technology)

		IFT81	TPCN1
Description		intraflagellar transport 81	two pore segment channel 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Centrosome Cilium Intraciliary Transport Particle B Motile Cilium Ciliary Basal Body Ciliary Tip	Lysosome Lysosomal Membrane Endosome Endosome Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Tubulin Binding	Voltage-gated Calcium Channel Activity Voltage-gated Sodium Channel Activity Protein Binding Ligand-gated Sodium Channel Activity Identical Protein Binding Protein Homodimerization Activity NAADP-sensitive Calcium-release Channel Activity Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process	Spermatogenesis Regulation Of Smoothened Signaling Pathway Intraciliary Transport Involved In Cilium Assembly Intraciliary Transport Cilium Assembly	Positive Regulation Of Autophagy Ion Transmembrane Transport Regulation Of Ion Transmembrane Transport Sodium Ion Transmembrane Transport Release Of Sequestered Calcium Ion Into Cytosol
Pathways		Intraflagellar transport Intraflagellar transport	Stimuli-sensing channels
Drugs
Diseases
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Bipolar disorder ( 31043756) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Headache ( 29397368) Intelligence (MTAG) ( 29326435) Total intracranial volume ( 31530798)	Response to fenofibrate (adiponectin levels) ( 23149075)
Interacting Genes		2 interacting genes: APP IFT74
Entrez ID		28981	53373
HPRD ID		09266	18217
Ensembl ID		ENSG00000122970	ENSG00000186815
Uniprot IDs		A0A024RBJ1 Q8WYA0	B3KSG7 B7Z3R2 Q9ULQ1
PDB IDs
Enriched GO Terms of Interacting Partners?
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