RAPGEF1 and SLC20A1

Data Source:
BioGRID (two hybrid)

		RAPGEF1	SLC20A1
Description		Rap guanine nucleotide exchange factor 1	solute carrier family 20 member 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Early Endosome Cytosol Phagocytic Vesicle Membrane Protein-containing Complex Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm	Plasma Membrane Integral Component Of Plasma Membrane Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding SH3 Domain Binding	Inorganic Phosphate Transmembrane Transporter Activity High-affinity Inorganic Phosphate:sodium Symporter Activity Sodium:phosphate Symporter Activity Signaling Receptor Activity
	Biological Process	Activation Of MAPKK Activity Blood Vessel Development Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Positive Regulation Of Neuron Projection Development Cytokine-mediated Signaling Pathway Rap Protein Signal Transduction Nerve Growth Factor Signaling Pathway Positive Regulation Of GTPase Activity Regulation Of JNK Cascade Positive Regulation Of Ras Protein Signal Transduction Negative Regulation Of Ras Protein Signal Transduction Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Protein Kinase B Signaling Establishment Of Endothelial Barrier Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Negative Regulation Of Canonical Wnt Signaling Pathway Activation Of GTPase Activity Cell-cell Adhesion Regulation Of Cell Junction Assembly Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Cellular Response To Nerve Growth Factor Stimulus Negative Regulation Of Neural Precursor Cell Proliferation	Phosphate-containing Compound Metabolic Process Ion Transport Viral Process Biomineral Tissue Development Phosphate Ion Transmembrane Transport Sodium Ion Transmembrane Transport Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Pathways		Frs2-mediated activation Frs2-mediated activation Downstream signal transduction MET activates RAP1 and RAC1 Erythropoietin activates RAS Erythropoietin activates RAS Regulation of signaling by CBL	Sodium-coupled phosphate cotransporters
Drugs
Diseases
GWAS		Cerebrospinal fluid Î±-synuclein levels ( 29959729) Cutaneous malignant melanoma ( 32341527) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Nevus count or cutaneous melanoma ( 32341527) Optic disc size ( 31809533)
Interacting Genes		19 interacting genes: ABL1 ATXN1 BCAR1 CRK CRKL EGFR GRB2 HCK HRAS MBIP NEDD9 RAP1A RAP1B RAP2B RHOQ RPS15 RRAS2 SHC1 SLC20A1	3 interacting genes: BCL10 MAPK6 RAPGEF1
Entrez ID		2889	6574
HPRD ID		02627	08846
Ensembl ID		ENSG00000107263	ENSG00000144136
Uniprot IDs		Q13905	A7LNJ1 Q8WUM9
PDB IDs		5L23
Enriched GO Terms of Interacting Partners?
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