LIN9 and MYBL2

Data Source:
HPRD (in vivo)

		LIN9	MYBL2
Description		lin-9 DREAM MuvB core complex component	MYB proto-oncogene like 2
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GO Annotations	Cellular Component	Nucleoplasm Transcription Repressor Complex	Nucleus Nucleoplasm Myb Complex
	Molecular Function	DNA Binding Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Reproduction Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Cell Cycle Regulation Of Cell Cycle DNA Biosynthetic Process	Mitotic Cell Cycle Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Mitotic Spindle Assembly Cellular Response To Leukemia Inhibitory Factor
Pathways		Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 Polo-like kinase mediated events Cyclin E associated events during G1/S transition G1/S-Specific Transcription Cyclin A:Cdk2-associated events at S phase entry	Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 Polo-like kinase mediated events TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation
Drugs
Diseases
GWAS		Caudate nucleus volume ( 31530798) Gut microbiota beta diversity (weighted UniFrac distance) ( 33208821) Mean corpuscular hemoglobin ( 32888494) Mean platelet volume ( 32888494) Nicotine dependence symptom count ( 25555482)	High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		3 interacting genes: MYBL2 RB1 RBBP4	31 interacting genes: CCNA1 CCNA2 CCND1 CCNE1 CCNF CDC34 CDK2 CDK9 CREBBP CXCR4 E2F1 E2F3 EP300 LIN52 LIN9 LZTR1 MAP1LC3B MAPK6 NCOR1 NCOR2 PARP1 RBBP4 RBL1 SKP2 SND1 TRIM15 TTF2 UBB UBE2D4 ZBTB9 ZNF622
Entrez ID		286826	4605
HPRD ID		13990	03247
Ensembl ID		ENSG00000183814	ENSG00000101057
Uniprot IDs		Q5TKA1 Q6P142	P10244
PDB IDs		6C48	6C48
Enriched GO Terms of Interacting Partners?
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