EMC10 and CCR2

Data Source:
BioGRID (two hybrid)

		EMC10	CCR2
Description		ER membrane protein complex subunit 10	C-C motif chemokine receptor 2
Image
GO Annotations	Cellular Component	Extracellular Region Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane EMC Complex	Cytoplasm Cytosol Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Dendrite Neuronal Cell Body Perikaryon Perinuclear Region Of Cytoplasm
	Molecular Function	Membrane Insertase Activity	Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding CCR2 Chemokine Receptor Binding Identical Protein Binding
	Biological Process	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Migration Protein Insertion Into ER Membrane By Stop-transfer Membrane-anchor Sequence Positive Regulation Of Angiogenesis Tail-anchored Membrane Protein Insertion Into ER Membrane Positive Regulation Of P38MAPK Cascade	Blood Vessel Remodeling Dendritic Cell Chemotaxis Regulation Of T Cell Cytokine Production Positive Regulation Of T-helper 1 Type Immune Response Negative Regulation Of Type 2 Immune Response Cellular Calcium Ion Homeostasis Chemotaxis Inflammatory Response Immune Response Cellular Defense Response G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Receptor Signaling Pathway Via JAK-STAT Response To Wounding Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of T Cell Chemotaxis Viral Process Negative Regulation Of Angiogenesis Cytokine-mediated Signaling Pathway Sensory Perception Of Pain Calcium-mediated Signaling Cellular Homeostasis Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Tumor Necrosis Factor Production Monocyte Extravasation T-helper 17 Cell Chemotaxis Negative Regulation Of Eosinophil Degranulation Regulation Of T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Proliferation Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Positive Regulation Of T Cell Activation Positive Regulation Of Synaptic Transmission, Glutamatergic Cell Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Immune Complex Clearance By Monocytes And Macrophages Inflammatory Response To Wounding Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of NMDA Glutamate Receptor Activity Macrophage Migration Positive Regulation Of Thymocyte Migration Positive Regulation Of Monocyte Extravasation Positive Regulation Of CD8-positive, Alpha-beta T Cell Extravasation Positive Regulation Of Astrocyte Chemotaxis Positive Regulation Of Hematopoietic Stem Cell Migration
Pathways			Beta defensins Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling
Drugs			INCB3284 CCX915 Plozalizumab
Diseases
GWAS		Age-related cognitive decline (memory) (slope of z-scores) ( 30954325)	Blood protein levels ( 28240269 23696881) Celiac disease ( 22057235 20190752 25920553 24999842) Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 26192919) Monocyte count ( 29403010 27863252) Monocyte percentage of white cells ( 32888494 27863252) Obesity-related traits ( 23251661) Rheumatoid arthritis ( 32868391) Ulcerative colitis ( 26192919 28067908)
Interacting Genes		3 interacting genes: CCR2 OXTR SMO	40 interacting genes: APP ARL6IP5 ATP2B1 B3GAT3 BLOC1S6 CACYBP CD59 CD81 CDIP1 CLPTM1 DMWD EMC10 ERGIC3 GOT1 GPR161 HERPUD1 HMOX2 JPH3 NDFIP1 NOTCH2 NTNG2 PCMT1 PLLP PTPN9 RGR RHOG RTN3 S1PR5 SCG5 SLC2A1 SLC41A3 SRSF5 SUMO1 SVOP TECPR2 TMEM161A TMEM199 TMEM63A TSPAN7 WLS
Entrez ID		284361	729230
HPRD ID		14153	19667
Ensembl ID		ENSG00000161671	ENSG00000121807
Uniprot IDs		Q5UCC4	A0A024R2Q0 P41597
PDB IDs		6WW7 6Z3W	1KAD 1KP1 2MLO 2MLQ 5T1A
Enriched GO Terms of Interacting Partners?
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