GPR17 and GLA

Data Source:
HPRD (in vitro)

		GPR17	GLA
Description		G protein-coupled receptor 17	galactosidase alpha
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Extracellular Region Cytoplasm Lysosome Golgi Apparatus Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome
	Molecular Function	G Protein-coupled Receptor Activity Chemokine Receptor Activity Receptor Serine/threonine Kinase Binding	Catalytic Activity Alpha-galactosidase Activity Signaling Receptor Binding Protein Binding Hydrolase Activity Galactosylgalactosylglucosylceramidase Activity Protein Homodimerization Activity Raffinose Alpha-galactosidase Activity
	Biological Process	Negative Regulation Of Inflammatory Response To Antigenic Stimulus G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Rho Protein Signal Transduction Oligodendrocyte Differentiation Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Chemokine-mediated Signaling Pathway	Glycosphingolipid Metabolic Process Oligosaccharide Metabolic Process Glycoside Catabolic Process Neutrophil Degranulation Negative Regulation Of Nitric Oxide Biosynthetic Process Glycosylceramide Catabolic Process Glycosphingolipid Catabolic Process Negative Regulation Of Nitric-oxide Synthase Activity
Pathways		Leukotriene receptors G alpha (q) signalling events P2Y receptors G alpha (i) signalling events	Glycosphingolipid metabolism Neutrophil degranulation
Drugs			Migalastat
Diseases			Fabry disease
GWAS		Proportion of activated microglia (inferior temporal cortex) ( 30679421)
Interacting Genes		2 interacting genes: GNA13 GPR37	1 interacting genes: TERT
Entrez ID		2840	2717
HPRD ID		04351	02357
Ensembl ID		ENSG00000144230	ENSG00000102393
Uniprot IDs		G4XH68 Q13304	P06280 Q53Y83
PDB IDs			1R46 1R47 3GXN 3GXP 3GXT 3HG2 3HG3 3HG4 3HG5 3LX9 3LXA 3LXB 3LXC 3S5Y 3S5Z 3TV8 4NXS 6IBK 6IBM 6IBR 6IBT
Enriched GO Terms of Interacting Partners?
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