GOLGA4 and MACF1

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		GOLGA4	MACF1
Description		golgin A4	microtubule actin crosslinking factor 1
Image
GO Annotations	Cellular Component	Golgi Membrane Nucleoplasm Cytoplasm Golgi Apparatus Trans-Golgi Network Cytosol Extracellular Exosome	Cytoplasm Golgi Apparatus Cytoskeleton Microtubule Intermediate Filament Plasma Membrane Actin Cytoskeleton Membrane Ruffle Membrane
	Molecular Function	Protein Binding Small GTPase Binding GTPase Binding	RNA Binding Actin Binding Structural Molecule Activity Calcium Ion Binding Protein Binding ATPase Activity Cadherin Binding Microtubule Minus-end Binding Actin Filament Binding
	Biological Process	Vesicle-mediated Transport Golgi To Plasma Membrane Protein Transport Positive Regulation Of Axon Extension Golgi Vesicle Transport	Regulation Of Epithelial Cell Migration Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Regulation Of Cell Migration Regulation Of Microtubule-based Process Wound Healing Golgi To Plasma Membrane Protein Transport Intermediate Filament Cytoskeleton Organization Positive Regulation Of Axon Extension Regulation Of Focal Adhesion Assembly Regulation Of Neuron Projection Arborization
Pathways		Retrograde transport at the Trans-Golgi-Network Signaling by membrane-tethered fusions of PDGFRA or PDGFRB
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Pulse pressure ( 30578418) Subjective response to lithium treatment ( 26503763)	Adult body size ( 32376654) Beard thickness ( 26926045) Body mass index ( 29273807) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Colorectal cancer ( 27207650) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Glucagon levels in response to oral glucose tolerance test (fasting) ( 29093273) HDL cholesterol ( 25961943 20686565) Headache ( 29397368) Heel bone mineral density ( 30598549) Loneliness (multivariate analysis) ( 27629369) Mean corpuscular hemoglobin concentration ( 27863252) Optic disc size ( 31809533) Peripheral arterial disease (traffic-related air pollution interaction) ( 27082954) Platelet distribution width ( 32888494) PR interval ( 32439900) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 32154731) Type 2 diabetes ( 27189021 30054458 29358691 30297969 29632382 32499647 28869590) Type 2 diabetes (adjusted for BMI) ( 29632382)
Interacting Genes		8 interacting genes: APP ARL1 ARL3 MACF1 RAB6A SERPINB5 TNIK TRAF3IP1	30 interacting genes: ACTA1 APC ATF7IP CDC5L CEP63 CNTNAP2 CNTNAP4 DISC1 DTNBP1 ESRRA EXOC1 FHL1 GOLGA4 JUN MAPK9 MAPRE1 MTNR1B NRCAM NRXN1 NRXN2 PLXND1 PRKCD SKIL SNAPIN SRPK2 TANGO6 TENM1 TNIK TRAF3IP1 UBC
Entrez ID		2803	23499
HPRD ID		03941	09750
Ensembl ID		ENSG00000144674	ENSG00000127603
Uniprot IDs		Q13439 Q49A56	Q6ZSD7 Q9UPN3
PDB IDs		1R4A 1UPT	4Z6G 5VE9 5X57
Enriched GO Terms of Interacting Partners?
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