GNGT2 and KCNJ4

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		GNGT2	KCNJ4
Description		G protein subunit gamma transducin 2	potassium inwardly rectifying channel subfamily J member 4
Image		No pdb structure
GO Annotations	Cellular Component	Heterotrimeric G-protein Complex Plasma Membrane G-protein Beta/gamma-subunit Complex	Plasma Membrane Voltage-gated Potassium Channel Complex Basolateral Plasma Membrane Cytoplasmic Vesicle Membrane Postsynaptic Membrane
	Molecular Function	GTPase Activity G-protein Beta-subunit Binding	Inward Rectifier Potassium Channel Activity Protein Binding PDZ Domain Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Phototransduction	Potassium Ion Transport Regulation Of Ion Transmembrane Transport Cardiac Conduction Potassium Ion Import Across Plasma Membrane
Pathways		Activation of G protein gated Potassium channels G-protein activation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling ADORA2B mediated anti-inflammatory cytokines production Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	Activation of G protein gated Potassium channels Classical Kir channels Phase 4 - resting membrane potential Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs			Ranolazine Miconazole Carvedilol Dronedarone
Diseases
GWAS		Asthma ( 31619474) Metabolite levels ( 23823483) Prostate cancer ( 23535732) Refractive error ( 32231278)	Automobile speeding propensity ( 30643258) Chronotype ( 30696823) Conotruncal heart defects ( 24800985) TPE interval (resting) ( 32386560)
Interacting Genes		3 interacting genes: GNB4 KCNJ4 SRPK2	11 interacting genes: CASK DLG1 DLG2 DLG4 GNGT2 GPR35 IL16 KCNJ2 LIN7B PRKCD SNTA1
Entrez ID		2793	3761
HPRD ID		06792	02738
Ensembl ID		ENSG00000167083	ENSG00000168135
Uniprot IDs		O14610	A0A024R1L8 P48050 Q58F07
PDB IDs			3GJ9
Enriched GO Terms of Interacting Partners?
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